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Verfasst von:Langer, Rupert [VerfasserIn]   i
 Mutze, Kathrin Isabelle Amelie [VerfasserIn]   i
 Becker, Karen [VerfasserIn]   i
 Feith, Marcus [VerfasserIn]   i
 Ott, Katja [VerfasserIn]   i
 Höfler, Heinz [VerfasserIn]   i
 Keller, Gisela [VerfasserIn]   i
Titel:Expression of class I histone deacetylases (HDAC1 and HDAC2) in oesophageal adenocarcinomas
Titelzusatz:an immunohistochemical study
Verf.angabe:Rupert Langer, Kathrin Mutze, Karen Becker, Marcus Feith, Katja Ott, Heinz Höfler, Gisela Keller
E-Jahr:2010
Jahr:5 October 2010
Umfang:5 S.
Fussnoten:Gesehen am 09.03.2023
Titel Quelle:Enthalten in: Journal of clinical pathology
Ort Quelle:London : BMJ Publ. Group, 1947
Jahr Quelle:2010
Band/Heft Quelle:63(2010), 11 vom: Okt., Seite 994-998
ISSN Quelle:1472-4146
Abstract:Background Histone deacetylases (HDACs) are enzymes which play a central role in post-translational histone and non-histone protein modification. Deregulation of HDACs has been detected in various human malignancies and may also influence response to chemotherapy. - Aims To investigate the expression of class I histone deacetylase (HDAC) isoforms 1 and 2 in oesophageal adenocarcinomas. - Methods 132 primary resected tumours and 48 tumours treated by chemotherapy were analysed. Expression of HDAC1 and HDAC2 was determined by immunohistochemistry, applied on a tissue microarray and on pretherapeutic biopsies, and correlated with pathological features and prognosis. - Results There was negative or low expression of HDAC1 in 54% of tumours, moderate expression in 41% and high expression in 5%. HDAC2 expression was negative or low in 30% of tumours, moderate in 47% and high in 21%. In primary resected tumours, high HDAC2 levels were associated with lymphatic tumour spread and lower tumour differentiation grade. HDAC1 levels were not associated with pT, pN category or tumour differentiation grade. For neoadjuvant treated tumours, there was only a trend for an association with high pretherapeutic HDAC2 expression and tumour regression after chemotherapy. Pretherapeutic HDAC1 levels were not associated with regression after chemotherapy. Survival analysis failed to show any prognostic impact of HDAC1 or HDAC2 expression. - Conclusions High HDAC2 expression is associated with aggressive tumour behaviour in oesophageal adenocarcinomas. No significant prognostic value could be found with respect to overall survival or an association with response to conventional chemotherapy for HDAC expression. Immunohistochemical determination of HDACs may be useful for prediction of response to specific HDAC inhibitors.
DOI:doi:10.1136/jcp.2010.080952
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1136/jcp.2010.080952
 Volltext: https://jcp.bmj.com/content/63/11/994
 DOI: https://doi.org/10.1136/jcp.2010.080952
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chemotherapy
 chemotherapy response
 expression
 GI neoplasms, oncology
 HDAC
 Histone deacetylase
 oesophagus adenocarcinoma
 tumour markers
K10plus-PPN:1838751289
Verknüpfungen:→ Zeitschrift

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