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Verfasst von:Langer, Rupert [VerfasserIn]   i
 Ott, Katja [VerfasserIn]   i
 Feith, Marcus [VerfasserIn]   i
 Lordick, Florian [VerfasserIn]   i
 Specht, Katja [VerfasserIn]   i
 Becker, Karen [VerfasserIn]   i
 Hofler, Heinz [VerfasserIn]   i
Titel:High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients
Verf.angabe:Rupert Langer, Katja Ott, Marcus Feith, Florian Lordick, Katja Specht, Karen Becker, and Heinz Hofler
E-Jahr:2010
Jahr:29 June 2010
Umfang:6 S.
Fussnoten:Gesehen am 09.03.2023
Titel Quelle:Enthalten in: Journal of surgical oncology
Ort Quelle:Bognor Regis [u.a.] : Wiley, 1996
Jahr Quelle:2010
Band/Heft Quelle:102(2010), 5 vom: Juni, Seite 503-508
ISSN Quelle:1096-9098
Abstract:Background The aim of this study was to determine whether pretherapeutic protein expression levels of the excision repair cross-complementing (ERCC1) enzyme, thymidylate synthetase (TS), multidrug-resistance protein 1 (MRP-1) and P-glycoprotein (P-gp) are associated with tumour response to cisplatin and fluorouracil (5-FU)-based neoadjuvant chemotherapy in oesophageal adenocarcinomas Methods The expression levels of ERCC1, TS, MDR-1 and P-gp were determined immunohistochemically in pretherapeutic tumour biopsies from 40 oesophageal adenocarcinoma patients and were correlated with histopathological tumour regression and with patient survival. Protein expression was compared to mRNA data, which was previously published for ERCC1, TS and MRP-1 and newly determined for the purpose of this study for MDR-1/P-gp. Results High-TS and -MRP-1 protein expression was correlated with tumour non-response to chemotherapy (P = 0.001 and P = 0.036, respectively). For ERCC-1 and P-gp, no association between pretherapeutic protein expression and response was found. There was no correlation between mRNA levels and protein expression for all investigated markers. Survival analysis revealed a trend towards increased survival for low-ERCC-1 expression (P = 0.079). Conclusions The pattern of pretherapeutic expression of TS and MRP-1 is related to chemotherapy response in oesophageal adenocarcinoma patients. Immunohistochemical assessment of these markers may be helpful for response prediction.
DOI:doi:10.1002/jso.21641
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/jso.21641
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.21641
 DOI: https://doi.org/10.1002/jso.21641
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chemotherapy
 MRP-1
 oesophageal adenocarcinoma
 thymidylate synthetase
K10plus-PPN:1838751637
Verknüpfungen:→ Zeitschrift

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