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Verfasst von:McDonough, Rosalie [VerfasserIn]   i
 Hacke, Werner [VerfasserIn]   i
Titel:Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment
Titelzusatz:a HERMES substudy
Verf.angabe:Rosalie V. McDonough, Johanna M. Ospel, Charles B.L.M. Majoie, Jeffrey L. Saver, Philip White, Diederik W.J. Dippel, Scott B. Brown, Andrew M. Demchuk, Tudor G. Jovin, Peter J. Mitchell, Serge Bracard, Bruce C.V. Campbell, Keith W. Muir, Michael D. Hill, Francis Guillemin, Mayank Goyal, on behalf of the HERMES collaborators... Werner Hacke [und viele weitere]
Jahr:2023
Umfang:7 S.
Fussnoten:published online first 24 February 2022 ; Gesehen am 09.03.2023
Titel Quelle:Enthalten in: Journal of neuroInterventional surgery
Ort Quelle:London : BMJ Journals, 2009
Jahr Quelle:2023
Band/Heft Quelle:15(2023), 3, Seite 214-220
ISSN Quelle:1759-8486
Abstract:BACKGROUND: Analyses of the effect of pre-stroke functional levels on the outcome of endovascular therapy (EVT) have focused on the course of patients with moderate to substantial pre-stroke disability. The effect of complete freedom from pre-existing disability (modified Rankin Scale (mRS) 0) versus predominantly mild pre-existing disability/symptoms (mRS 1-2) has not been well delineated. METHODS: The HERMES meta-analysis pooled data from seven randomized trials that tested the efficacy of EVT. We tested for a multiplicative interaction effect of pre-stroke mRS on the relationship between treatment and outcomes. Ordinal regression was used to assess the association between EVT and 90-day mRS (primary outcome) in the subgroup of patients with pre-stroke mRS 1-2. Multivariable regression modeling was then used to test the effect of mild pre-stroke disability/symptoms on the primary and secondary outcomes (delta-mRS, mRS 0-2/5-6) compared with patients with pre-stroke mRS 0. RESULTS: We included 1764 patients, of whom 199 (11.3%) had pre-stroke mRS 1-2. No interaction effect of pre-stroke mRS on the relationship between treatment and outcome was observed. Patients with pre-stroke mRS 1-2 had worse outcomes than those with pre-stroke mRS 0 (adjusted common OR (acOR) 0.53, 95% CI 0.40 to 0.70). Nonetheless, a significant benefit of EVT was observed within the mRS 1-2 subgroup (cOR 2.08, 95% CI 1.22 to 3.55). CONCLUSIONS: Patients asymptomatic/without disability prior to onset have better outcomes following EVT than patients with mild disability/symptoms. Patients with pre-stroke mRS 1-2, however, more often achieve good outcomes with EVT compared with conservative management. These findings indicate that mild pre-existing disability/symptoms influence patient prognosis after EVT but do not diminish the EVT treatment effect.
DOI:doi:10.1136/neurintsurg-2021-018428
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1136/neurintsurg-2021-018428
 DOI: https://doi.org/10.1136/neurintsurg-2021-018428
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Humans
 Brain Ischemia
 Endovascular Procedures
 stroke
 Stroke
 thrombectomy
 Thrombectomy
 Treatment Outcome
K10plus-PPN:1838759107
Verknüpfungen:→ Zeitschrift

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