CIC reduces xCT/SLC7A11 expression and glutamate release in glioma

• Verfasst von: Park, Jongwhi [VerfasserIn]
• Verfasst von: Kilic, Omer [VerfasserIn]
• Verfasst von: Deo, Minh [VerfasserIn]
• Verfasst von: Jimenez-Cowell, Kevin [VerfasserIn]
• Verfasst von: Demirdizen, Engin [VerfasserIn]
• Verfasst von: Kim, Hyunggee [VerfasserIn]
• Verfasst von: Turcan, S̨evin [VerfasserIn]
• Titel: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
• Verf.angabe: Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim and Şevin Turcan
• E-Jahr: 2023
• Jahr: 16 January 2023
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 15.11.2023
• Titel Quelle: Enthalten in: Acta Neuropathologica Communications
• Ort Quelle: London : Biomed Central, 2013
• Jahr Quelle: 2023
• Band/Heft Quelle: 11(2023), Artikel-ID 13, Seite 1-12
• ISSN Quelle: 2051-5960
• DOI: doi:10.1186/s40478-023-01507-y
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Capicua
• Sach-SW: Glutamate
• Sach-SW: Neuronal toxicity
• Sach-SW: Oligodendroglioma
• Sach-SW: xCT/SLC7A11
• K10plus-PPN: 1838976426
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived glioma lines, RNA-sequencing and bioinformatic analysis of publicly available databases, we investigated how CIC loss- or gain-of-function regulates its downstream targets, cell proliferation and glutamate release. Our results indicate an increased frequency of CIC truncating mutations in oligodendroglioma during progression. ...