An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen

• Verfasst von: Lemke, Andreas [VerfasserIn]
• Verfasst von: Laun, Frederik B. [VerfasserIn]
• Verfasst von: Simon, Dirk [VerfasserIn]
• Verfasst von: Stieltjes, Bram [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Titel: An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen
• Verf.angabe: Andreas Lemke, Frederik B. Laun, Dirk Simon, Bram Stieltjes, and Lothar R. Schad
• E-Jahr: 2010
• Jahr: 27 July 2010
• Umfang: 6 S.
• Fussnoten: Gesehen am 13.03.2023
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Ort Quelle: New York, NY [u.a.] : Wiley-Liss, 1984
• Jahr Quelle: 2010
• Band/Heft Quelle: 64(2010), 6 vom: Juli, Seite 1580-1585
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.22565
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: diffusion
• Sach-SW: IVIM
• Sach-SW: pancreas
• Sach-SW: relaxation effects
• K10plus-PPN: 1839014717

Abstract

To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo times (TE = 50, 70, and 100 msec). The perfusion fraction f and the diffusion coefficient D were extracted from the measured DW-data using the original Intra Voxel Incoherent Motion-equation and a modified version of this equation incorporating relaxation effects. First, the perfusion fraction f in the blood suppressed pancreatic tissue decreased significantly (P = 0.03), whereas the diffusion coefficient D did not change with suppression (P = 0.43). Second, the perfusion fraction f increased significantly with increasing echo time (P = 0.0025), whereas the relaxation time compensated perfusion fraction f′ showed no significant dependence on TE (P = 0.31). These results verify a vascular contribution to the diffusion weighted imaging measurement at low b values and support the Intra Voxel Incoherent Motion-theory.