Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis

• Verfasst von: Leowardi-Bauer, Christine [VerfasserIn]
• Verfasst von: Hinz, Ulf [VerfasserIn]
• Verfasst von: Tariverdian, Mirjam [VerfasserIn]
• Verfasst von: Kienle, Peter [VerfasserIn]
• Verfasst von: Herfarth, Christian [VerfasserIn]
• Verfasst von: Ulrich, Alexis [VerfasserIn]
• Verfasst von: Kadmon, Martina [VerfasserIn]
• Titel: Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis
• Verf.angabe: Christine Leowardi, Ulf Hinz, Mirjam Tariverdian, Peter Kienle, Christian Herfarth, Alexis Ulrich, Martina Kadmon
• Jahr: 2010
• Umfang: 8 S.
• Fussnoten: Online veröffentlicht: 12. März 2009 ; Gesehen am 13.03.2023
• Titel Quelle: Enthalten in: Langenbeck's archives of surgery
• Ort Quelle: Berlin : Springer, 1948
• Jahr Quelle: 2010
• Band/Heft Quelle: 395(2010), 1, Seite 49-56
• ISSN Quelle: 1435-2451
• DOI: doi:10.1007/s00423-009-0479-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Ileal pouch-anal anastomosis
• Sach-SW: Long-term quality of life
• Sach-SW: Pouch failure
• Sach-SW: Ulcerative colitis
• K10plus-PPN: 1839019808

Abstract

Purpose: The aim of this study was to assess quality of life (QOL) in a long-term follow-up of patients with ulcerative colitis (UC) 10 years and more after ileal pouch–anal anastomosis (IPAA) to correlate these results with pouch function and to assess the long-term pouch failure rate. Methods: In a unicentric study, 294 consecutive patients after IPAA between 1988 and 1996 were identified from a prospective database. QOL was evaluated according to the validated Gastrointestinal Quality of Life Index (GIQLI). Results: Overall median follow-up was 11.5 years. Thirty-seven patients experienced pouch failure (12.6%). The rates of ileal pouch success after 5, 10 and 15 years were 92.3%, 88.7% and 84.5%. According to the GIQLI, patients with a functioning pouch achieved a mean score of 107.8, reflecting a decrease of QOL of 10.8% compared to a healthy population. There were significant negative correlations between QOL and an age of >50 years (p < 0.05), pouchitis, perianal inflammation and increased stool frequency (p < 0.0001). Conclusions: QOL and functional results of patients with UC 10 years or more after IPAA were acceptable; however, those were reduced when compared to a healthy population. Pouch failure rate still increases up to 15.5% 15 years after IPAA. This result represents an important issue in providing patients with comprehensive preoperative information.