| |  Online-Ressource |
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| Verfasst von: | Chirasani, Sridhar Reddy [VerfasserIn]  |
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| | Sternjak, Alexander [VerfasserIn] |
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| | Wend, Peter [VerfasserIn] |
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| | Momma, Stefan [VerfasserIn] |
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| | Campos, Benito [VerfasserIn] |
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| | Herrmann, Ilaria Marta [VerfasserIn] |
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| | Graf, Daniel [VerfasserIn] |
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| | Mitsiadis, Thimios [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Besser, Daniel [VerfasserIn] |
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| | Synowitz, Michael [VerfasserIn] |
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| | Kettenmann, Helmut [VerfasserIn] |
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| | Glass, Rainer [VerfasserIn] |
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| Titel: | Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells |
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| Verf.angabe: | Sridhar Reddy Chirasani, Alexander Sternjak, Peter Wend, Stefan Momma, Benito Campos, Ilaria M. Herrmann, Daniel Graf, Thimios Mitsiadis, Christel Herold-Mende, Daniel Besser, Michael Synowitz, Helmut Kettenmann and Rainer Glass |
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| E-Jahr: | 2010 |
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| Jahr: | May 30, 2010 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 13.03.2023 |
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| Titel Quelle: | Enthalten in: Brain |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1878 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 133(2010), Pt 7, Seite 1961-1972 |
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| ISSN Quelle: | 1460-2156 |
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| Abstract: | Glioblastoma cells with stem-like properties control brain tumour growth and recurrence. Here, we show that endogenous neural precursor cells perform an anti-tumour response by specifically targeting stem-like brain tumour cells. In vitro, neural precursor cells predominantly express bone morphogenetic protein-7; bone morphogenetic protein-7 is constitutively released from neurospheres and induces canonical bone morphogenetic protein signalling in stem-like glioblastoma cells. Exposure of human and murine stem-like brain tumour cells to neurosphere-derived bone morphogenetic protein-7 induces tumour stem cell differentiation, attenuates stem-like marker expression and reduces self-renewal and the ability for tumour initiation. Neurosphere-derived or recombinant bone morphogenetic protein-7 reduces glioblastoma expansion from stem-like cells by down-regulating the transcription factor Olig2. In vivo, large numbers of bone morphogenetic protein-7-expressing neural precursors encircle brain tumours in young mice, induce canonical bone morphogenetic protein signalling in stem-like glioblastoma cells and can thereby attenuate tumour formation. This anti-tumour response is strongly reduced in older mice. Our results indicate that endogenous neural precursor cells protect the young brain from glioblastoma by releasing bone morphogenetic protein-7, which acts as a paracrine tumour suppressor that represses proliferation, self-renewal and tumour-initiation of stem-like glioblastoma cells. |
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| DOI: | doi:10.1093/brain/awq128 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/brain/awq128 |
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| | DOI: https://doi.org/10.1093/brain/awq128 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Bone Morphogenetic Protein 7 |
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| | Brain Neoplasms |
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| | Glioblastoma |
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| | Humans |
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| | Mice |
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| | Mice, Inbred C57BL |
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| | Mice, Inbred NOD |
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| | Mice, SCID |
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| | Neoplastic Stem Cells |
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| | Neurons |
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| | Stem Cells |
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| | Tumor Cells, Cultured |
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| K10plus-PPN: | 1839021713 |
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| Verknüpfungen: | → Zeitschrift |
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Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells / Chirasani, Sridhar Reddy [VerfasserIn]; May 30, 2010 (Online-Ressource)
