| |  Online-Ressource |
|---|
| Verfasst von: | Kisielewicz, Anna [VerfasserIn]  |
|---|
| | Schaier, Matthias [VerfasserIn] |
|---|
| | Schmitt, Edgar [VerfasserIn] |
|---|
| | Hug, Friederike [VerfasserIn] |
|---|
| | Hänsch, Gertrud Maria [VerfasserIn] |
|---|
| | Meuer, Stefan [VerfasserIn] |
|---|
| | Zeier, Martin [VerfasserIn] |
|---|
| | Sohn, Christof [VerfasserIn] |
|---|
| | Steinborn-Kröhl, Andrea [VerfasserIn] |
|---|
| Titel: | A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation |
|---|
| Verf.angabe: | Anna Kisielewicz, Matthias Schaier, Edgar Schmitt, Friederike Hug, Gertrud M. Haensch, Stefan Meuer, Martin Zeier, Christof Sohn, Andrea Steinborn |
|---|
| E-Jahr: | 2010 |
|---|
| Jahr: | 6 September 2010 |
|---|
| Umfang: | 12 S. |
|---|
| Fussnoten: | Im Titel erscheint das Zeichen + hochgestellt ; Gesehen am 14.03.2023 |
|---|
| Titel Quelle: | Enthalten in: Clinical immunology |
|---|
| Ort Quelle: | San Diego, Calif. : Elsevier, 1999 |
|---|
| Jahr Quelle: | 2010 |
|---|
| Band/Heft Quelle: | 137(2010), 2 vom: Nov., Seite 209-220 |
|---|
| ISSN Quelle: | 1521-7035 |
|---|
| Abstract: | Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3+DR+-Tregs among the total CD4+CD127low+/−CD25+-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3+DR+-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4+CD127low+/−CD25+-Treg cell pool. Our findings propose that the FoxP3+DR+-Treg subset may be decisively responsible for the suppressive activity of the total CD4+CD127low+/−CD25+-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation. |
|---|
| DOI: | doi:10.1016/j.clim.2010.07.008 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.clim.2010.07.008 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S1521661610006741 |
|---|
| | DOI: https://doi.org/10.1016/j.clim.2010.07.008 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Pregnancy |
|---|
| | Preterm labor |
|---|
| | Regulatory T cells |
|---|
| | Renal transplantation |
|---|
| | Tolerance induction |
|---|
| | Transplant rejection |
|---|
| K10plus-PPN: | 1839092858 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬A¬ distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation / Kisielewicz, Anna [VerfasserIn]; 6 September 2010 (Online-Ressource)
