Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hofmann, Jennifer Carina [VerfasserIn]   i
 Husedzinovic, Alma [VerfasserIn]   i
 Gruss, Oliver [VerfasserIn]   i
Titel:The function of spliceosome components in open mitosis
Verf.angabe:Jennifer C. Hofmann, Alma Husedzinovic and Oliver J. Gruss (DKFZ-ZMBH-Alliance, ZMBH, Heidelberg)
E-Jahr:2010
Jahr:31 Dec 2010
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 14.03.2023
Titel Quelle:Enthalten in: Nucleus
Ort Quelle:Austin, Tex. : Landes Bioscience, 2010
Jahr Quelle:2010
Band/Heft Quelle:1(2010), 6 vom: Dez., Seite 447-459
ISSN Quelle:1949-1042
Abstract:Spatial separation of eukaryotic cells into the nuclear and cytoplasmic compartment permits uncoupling of DNA transcription from translation of mRNAs, and allows cells to modify newly transcribed pre mRNAs extensively. Intronic sequences (introns), which interrupt the coding elements (exons), are excised (“spliced”) from pre mRNAs in the nucleus to yield mature mRNAs. This not only enables alternative splicing as an important source of proteome diversity. Splicing is also an essential process in all eukaryotes and knock-out or knock-down of splicing factors frequently results in defective cell proliferation and cell division. However, higher eukaryotes progress through cell division only after breakdown of the nucleus (“open mitosis”). Open mitosis suppresses basic nuclear functions such as transcription and splicing, but allows separate, mitotic functions of nuclear proteins in cell division. Mitotic defects arising after loss-of-function of splicing proteins therefore could be an indirect consequence of compromised splicing in the closed nucleus of the preceding interphase, or reflect a direct contribution of splicing proteins to open mitosis. Although experiments to directly distinguish between these two alternatives have not been reported, indirect evidence exists for either hypotheses. In this review, we survey published data supporting an indirect function of splicing in open mitosis or arguing for a direct function of spliceosomal proteins in cell division.
DOI:doi:10.4161/nucl.1.6.13328
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.4161/nucl.1.6.13328
 DOI: https://doi.org/10.4161/nucl.1.6.13328
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1839105925
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69051527   QR-Code
zum Seitenanfang