| |  Online-Ressource |
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| Verfasst von: | Klemke, Martin [VerfasserIn]  |
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| | Kramer, Elisabeth [VerfasserIn] |
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| | Konstandin, Mathias [VerfasserIn] |
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| | Wabnitz, Guido H. [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| Titel: | An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments |
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| Verf.angabe: | Martin Klemke, Elisabeth Kramer, Mathias H Konstandin, Guido H Wabnitz and Yvonne Samstag |
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| E-Jahr: | 2010 |
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| Jahr: | 30 July 2010 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 14.03.2023 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationThe EMBO journal |
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| Ort Quelle: | Heidelberg : EMBO Press, 1982 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 29(2010), 17 vom: Sept., Seite 2915-2929 |
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| ISSN Quelle: | 1460-2075 |
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| Abstract: | T cells infiltrate peripheral tissues to execute immunosurveillance and effector functions. For this purpose, T cells first migrate on the two-dimensional (2D) surface of endothelial cells to undergo transendothelial migration. Then they change their mode of movement to undergo migration within the three-dimensional (3D)-extracellular matrix of the infiltrated tissue. As yet, no molecular mechanisms are known, which control migration exclusively in either 2D or 3D environments. Here, we describe a signalling module that controls T-cell chemotaxis specifically in 3D environments. In chemotaxing T cells, Ras activity is spatially restricted to the lamellipodium. There, Ras initiates activation of MEK, which in turn inhibits LIM-kinase 1 activity, thereby allowing dephosphorylation of the F-actin-remodelling protein cofilin. Interference with this MEK-cofilin module by either inhibition of MEK or by knockdown of cofilin reduces speed and directionality of chemotactic migration in 3D-extracellular matrices, but not on 2D substrates. This MEK-cofilin module may have an important function in the tissue positioning of T cells during an immune response. |
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| DOI: | doi:10.1038/emboj.2010.153 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/emboj.2010.153 |
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| | Volltext: https://www.embopress.org/doi/full/10.1038/emboj.2010.153 |
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| | DOI: https://doi.org/10.1038/emboj.2010.153 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | actin cytoskeleton |
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| | cell migration |
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| | chemotaxis |
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| | cofilin |
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| | extracellular matrix |
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| K10plus-PPN: | 1839131969 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments / Klemke, Martin [VerfasserIn]; 30 July 2010 (Online-Ressource)
