Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Buckup, Tiago [VerfasserIn]  |
| Southan, A. [VerfasserIn]  |
| Kim, H. -C. [VerfasserIn]  |
| Hampp, N. [VerfasserIn]  |
| Motzkus, Marcus [VerfasserIn]  |
Titel: | Optimisation of two-photon induced cleavage of molecular linker systems for drug delivery |
Verf.angabe: | T. Buckup, A. Southan, H.-C. Kim, N. Hampp, M. Motzkus |
Jahr: | 2010 |
Umfang: | 5 S. |
Fussnoten: | Erstmals am 23. Dezember 2009 online veröffentlicht ; Gesehen am 15.03.2023 |
Titel Quelle: | Enthalten in: Journal of photochemistry and photobiology |
Ort Quelle: | New York, NY [u.a.] : Elsevier, 1987 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 210(2010), 2, Seite 188-192 |
ISSN Quelle: | 1873-2666 |
Abstract: | Photoreactive linker systems for drug delivery in modern ophthalmology are crucial for the efficiency of such applications. We compare 5 different linker molecule candidates (truxillic acid and 4 dimers of coumarin derivates) in solution regarding their chemical stability and two-photon induced cleavage efficiency, and shed light into the role of molecular structure in the cleavage reaction. Dimers of the coumarin family showed much higher two-photon induced cleavage efficiency, achieving the highest reaction cross-section when tert-Butyldimethylsilyl (TBS) was used as a substituent, being almost 5-times higher than the unsubstituted coumarin dimer. Coumarin-based linker systems react promptly with nucleophilic solvents, in particular with short chain alcohols. The polarity of such solvents which do not cause a lactone ring opening seems not to influence the cleavage of the cyclobutane ring in coumarin dimers. |
DOI: | doi:10.1016/j.jphotochem.2009.12.016 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jphotochem.2009.12.016 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1010603009004663 |
| DOI: https://doi.org/10.1016/j.jphotochem.2009.12.016 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Photo-induced cleavage |
| Reaction quantum yield |
K10plus-PPN: | 183924321X |
Verknüpfungen: | → Zeitschrift |
Optimisation of two-photon induced cleavage of molecular linker systems for drug delivery / Buckup, Tiago [VerfasserIn]; 2010 (Online-Ressource)
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