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| Verfasst von: | Kochlamazashvili, Gaga [VerfasserIn]  |
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| | Henneberger, Christian [VerfasserIn] |
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| | Bukalo, Olena [VerfasserIn] |
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| | Dvoretskova, Elena [VerfasserIn] |
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| | Senkov, Oleg [VerfasserIn] |
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| | Lievens, Patricia M. -J. [VerfasserIn] |
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| | Westenbroek, Ruth [VerfasserIn] |
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| | Engel, Andreas K. [VerfasserIn] |
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| | Catterall, William A. [VerfasserIn] |
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| | Rusakov, Dmitri A. [VerfasserIn] |
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| | Schachner, Melitta [VerfasserIn] |
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| | Dityatev, Alexander [VerfasserIn] |
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| Titel: | The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-Type Ca2+ channels |
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| Verf.angabe: | Gaga Kochlamazashvili, Christian Henneberger, Olena Bukalo, Elena Dvoretskova, Oleg Senkov, Patricia M. -J. Lievens, Ruth Westenbroek, Andreas K. Engel, William A. Catterall, Dmitri A. Rusakov, Melitta Schachner, and Alexander Dityatev |
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| E-Jahr: | 2010 |
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| Jahr: | July 14, 2010 |
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| Umfang: | 13 S. |
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| Fussnoten: | In Titel erscheinen die Zeichen 2+ in der chemischen Formel hochgestellt ; Gesehen am 16.03.2023 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 67(2010), 1 vom: Juli, Seite 116-128 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | Although the extracellular matrix plays an important role in regulating use-dependent synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we examined the synaptic function of hyaluronic acid (HA), a major component of the extracellular matrix. Enzymatic removal of HA with hyaluronidase reduced nifedipine-sensitive whole-cell Ca2+ currents, decreased Ca2+ transients mediated by L-type voltage-dependent Ca2+ channels (L-VDCCs) in postsynaptic dendritic shafts and spines, and abolished an L-VDCC-dependent component of long-term potentiation (LTP) at the CA3-CA1 synapses in the hippocampus. Adding exogenous HA, either by bath perfusion or via local delivery near recorded synapses, completely rescued this LTP component. In a heterologous expression system, exogenous HA rapidly increased currents mediated by Cav1.2, but not Cav1.3, subunit-containing L-VDCCs, whereas intrahippocampal injection of hyaluronidase impaired contextual fear conditioning. Our observations unveil a previously unrecognized mechanism by which the perisynaptic extracellular matrix influences use-dependent synaptic plasticity through regulation of dendritic Ca2+ channels. |
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| DOI: | doi:10.1016/j.neuron.2010.05.030 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neuron.2010.05.030 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0896627310004265 |
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| | DOI: https://doi.org/10.1016/j.neuron.2010.05.030 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | MOLNEURO |
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| | PROTEINS |
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| | SYSNEURO |
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| K10plus-PPN: | 1839349018 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-Type Ca2+ channels / Kochlamazashvili, Gaga [VerfasserIn]; July 14, 2010 (Online-Ressource)
