Trophoblast cell surface antigen 2 (Trop2) in chromophobe renal cell carcinoma

• Verfasst von: Mikuteit, Marie [VerfasserIn]
• Verfasst von: Steffens, Sandra [VerfasserIn]
• Verfasst von: Zschäbitz, Stefanie [VerfasserIn]
• Verfasst von: Autenrieth, Michael [VerfasserIn]
• Verfasst von: Weichert, Wilko [VerfasserIn]
• Verfasst von: Hartmann, Arndt [VerfasserIn]
• Verfasst von: Erlmeier, Franziska [VerfasserIn]
• Titel: Trophoblast cell surface antigen 2 (Trop2) in chromophobe renal cell carcinoma
• Verf.angabe: Marie Mikuteit, Sandra Steffens, Stefanie Zschäbitz, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Franziska Erlmeier
• E-Jahr: 2022
• Jahr: February 15, 2022
• Umfang: 6 S.
• Fussnoten: Gesehen am 20.03.2023
• Titel Quelle: Enthalten in: Oncology
• Ort Quelle: Basel : Karger, 1967
• Jahr Quelle: 2022
• Band/Heft Quelle: 100(2022), 6 vom: Mai, Seite 331-336
• ISSN Quelle: 1423-0232
• DOI: doi:10.1159/000522592
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1839540400

Abstract

Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2− compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.