| |  Online-Ressource |
|---|
| Verfasst von: | Rheinberger, Mona [VerfasserIn]  |
|---|
| | Costa, Ana Luisa [VerfasserIn] |
|---|
| | Kampmann, Martin [VerfasserIn] |
|---|
| | Glavas, Dunja [VerfasserIn] |
|---|
| | Shytaj, Iart Luca [VerfasserIn] |
|---|
| | Sreeram, Sheetal [VerfasserIn] |
|---|
| | Penzo, Carlotta [VerfasserIn] |
|---|
| | Tibroni, Nadine [VerfasserIn] |
|---|
| | Garcia-Mesa, Yoelvis [VerfasserIn] |
|---|
| | Leskov, Konstantin [VerfasserIn] |
|---|
| | Fackler, Oliver Till [VerfasserIn] |
|---|
| | Vlahovicek, Kristian [VerfasserIn] |
|---|
| | Karn, Jonathan [VerfasserIn] |
|---|
| | Lucic, Bojana [VerfasserIn] |
|---|
| | Herrmann, Carl [VerfasserIn] |
|---|
| | Lusic, Marina [VerfasserIn] |
|---|
| Titel: | Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains |
|---|
| Verf.angabe: | Mona Rheinberger, Ana Luisa Costa, Martin Kampmann, Dunja Glavas, Iart Luca Shytaj, Sheetal Sreeram, Carlotta Penzo, Nadine Tibroni, Yoelvis Garcia-Mesa, Konstantin Leskov, Oliver T. Fackler, Kristian Vlahovicek, Jonathan Karn, Bojana Lucic, Carl Herrmann, Marina Lusic |
|---|
| E-Jahr: | 2023 |
|---|
| Jahr: | 13 February 2023 |
|---|
| Umfang: | 27 S. |
|---|
| Fussnoten: | Gesehen am 21.03.2023 |
|---|
| Titel Quelle: | Enthalten in: Cell reports |
|---|
| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
|---|
| Jahr Quelle: | 2023 |
|---|
| Band/Heft Quelle: | 42(2023), 2 vom: Feb., Artikel-ID 112110, Seite 1-27 |
|---|
| ISSN Quelle: | 2211-1247 |
|---|
| Abstract: | HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 infection has been largely understudied across different HIV-1 targets. Here, we determine HIV-1 integration sites (ISs), associate them with chromatin and expression signatures at different genomic scales in a microglia cell model, and profile them together with the primary T cell reservoir. HIV-1 insertions into introns of actively transcribed genes with IS hotspots in genic and super-enhancers, characteristic of blood cells, are maintained in the microglia cell model. Genome organization analysis reveals dynamic CCCTC-binding factor (CTCF) clusters in cells with active and repressed HIV-1 transcription, whereas CTCF removal impairs viral integration. We identify CTCF-enriched topologically associated domain (TAD) boundaries with signatures of transcriptionally active chromatin as HIV-1 integration determinants in microglia and CD4+ T cells, highlighting the importance of host genome organization in HIV-1 infection. |
|---|
| DOI: | doi:10.1016/j.celrep.2023.112110 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2023.112110 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723001213 |
|---|
| | DOI: https://doi.org/10.1016/j.celrep.2023.112110 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | chromatin |
|---|
| | CTCF |
|---|
| | H3K36me3 |
|---|
| | HIV-1 integration sites |
|---|
| | latency |
|---|
| | microglia |
|---|
| | TAD |
|---|
| K10plus-PPN: | 1839651644 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains / Rheinberger, Mona [VerfasserIn]; 13 February 2023 (Online-Ressource)
