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Verfasst von:Kim, Ji-Young [VerfasserIn]   i
 Zschaeck, Sebastian [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Weykamp, Fabian [VerfasserIn]   i
Titel:Combined hyperthermia and re-irradiation in non-breast cancer patients
Titelzusatz:a systematic review
Verf.angabe:Ji-Young Kim, Sebastian Zschaeck, Jürgen Debus and Fabian Weykamp
E-Jahr:2023
Jahr:25 January 2023
Umfang:19 S.
Fussnoten:Gesehen am 21.03.2023
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2023
Band/Heft Quelle:15(2023), 3 vom: Jan., Artikel-ID 742, Seite 1-19
ISSN Quelle:2072-6694
Abstract:Purpose: This systematic literature review summarizes clinical studies and trials involving combined non-ablative hyperthermia and re-irradiation in locoregionally recurrent cancer except breast cancer. Methods: One database and one registry, MEDLINE and clinicaltrials.gov, respectively, were searched for studies on combined non-ablative hyperthermia and re-irradiation in non-breast cancer patients. Extracted study characteristics included treatment modalities and re-irradiation dose concepts. Outcomes of interest were tumor response, survival measures, toxicity data and palliation. Within-study bias assessment included the identification of conflict of interest (COI). The final search was performed on 29 August 2022. Results: Twenty-three articles were included in the final analysis, reporting on 603 patients with eight major tumor types. Twelve articles (52%) were retrospective studies. Only one randomized trial was identified. No COI statement was declared in 11 studies. Four of the remaining twelve studies exhibited significant COI. Low study and patient numbers, high heterogeneity in treatment modalities and endpoints, as well as significant within- and across-study bias impeded the synthesis of results. Conclusion: Outside of locoregionally recurrent breast cancer, the role of combined moderate hyperthermia and re-irradiation can so far not be established. This review underscores the necessity for more clinical trials to generate higher levels of clinical evidence for combined re-irradiation and hyperthermia.
DOI:doi:10.3390/cancers15030742
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/cancers15030742
 Volltext: https://www.mdpi.com/2072-6694/15/3/742
 DOI: https://doi.org/10.3390/cancers15030742
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:hyperthermia
 re-irradiation
K10plus-PPN:183965211X
Verknüpfungen:→ Zeitschrift

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