The dual nature of the nucleolus

• Verfasst von: Tartakoff, Alan [VerfasserIn]
• Verfasst von: DiMario, Patrick [VerfasserIn]
• Verfasst von: Hurt, Ed [VerfasserIn]
• Verfasst von: McStay, Brian [VerfasserIn]
• Verfasst von: Panse, Vikram Govind [VerfasserIn]
• Verfasst von: Tollervey, David [VerfasserIn]
• Titel: The dual nature of the nucleolus
• Verf.angabe: Alan Tartakoff, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, and David Tollervey
• Jahr: 2022
• Umfang: 5 S.
• Fussnoten: Gesehen am 21.03.2023
• Titel Quelle: Enthalten in: Genes & development
• Ort Quelle: Stanford, Calif. : HighWire Press, 1987
• Jahr Quelle: 2022
• Band/Heft Quelle: 36(2022), 13-14, Seite 765-769
• ISSN Quelle: 1549-5477
• DOI: doi:10.1101/gad.349748.122
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: condensates
• Sach-SW: nucleolus
• Sach-SW: ribosome genesis
• K10plus-PPN: 183965337X

Abstract

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.