| |  Online-Ressource |
|---|
| Verfasst von: | Kowarsch, Andreas [VerfasserIn]  |
|---|
| | Blöchl, Florian [VerfasserIn] |
|---|
| | Bohl, Sebastian [VerfasserIn] |
|---|
| | Saile, Maria [VerfasserIn] |
|---|
| | Gretz, Norbert [VerfasserIn] |
|---|
| | Klingmüller, Ursula [VerfasserIn] |
|---|
| | Theis, Fabian J. [VerfasserIn] |
|---|
| Titel: | Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation |
|---|
| Verf.angabe: | Andreas Kowarsch, Florian Blöchl, Sebastian Bohl, Maria Saile, Norbert Gretz, Ursula Klingmüller, Fabian J. Theis |
|---|
| E-Jahr: | 2010 |
|---|
| Jahr: | 30 November 2010 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 22.03.2023 |
|---|
| Titel Quelle: | Enthalten in: BMC bioinformatics |
|---|
| Ort Quelle: | London : BioMed Central, 2000 |
|---|
| Jahr Quelle: | 2010 |
|---|
| Band/Heft Quelle: | 11(2010), Artikel-ID 585, Seite 1-14 |
|---|
| ISSN Quelle: | 1471-2105 |
|---|
| Abstract: | External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gene expression. The analysis of such changes is complicated, as they consist of multi-layered temporal responses. While classical analyses based on clustering or gene set enrichment only partly reveal this information, matrix factorization techniques are well suited for a detailed temporal analysis. In signal processing, factorization techniques incorporating data properties like spatial and temporal correlation structure have shown to be robust and computationally efficient. However, such correlation-based methods have so far not be applied in bioinformatics, because large scale biological data rarely imply a natural order that allows the definition of a delayed correlation function. |
|---|
| DOI: | doi:10.1186/1471-2105-11-585 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/1471-2105-11-585 |
|---|
| | kostenfrei: Volltext: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-585 |
|---|
| | DOI: https://doi.org/10.1186/1471-2105-11-585 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Acute Phase Protein |
|---|
| | Gene Regulatory Network |
|---|
| | GraDe Algorithm |
|---|
| | Network Component Analysis |
|---|
| | Nonnegative Matrix Factorization |
|---|
| K10plus-PPN: | 1839798882 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation / Kowarsch, Andreas [VerfasserIn]; 30 November 2010 (Online-Ressource)
