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Verfasst von:Altersberger, Valerian L. [VerfasserIn]   i
 Rusche, Norman [VerfasserIn]   i
 Martinez-Majander, Nicolas [VerfasserIn]   i
 Hametner, Christian [VerfasserIn]   i
 Scheitz, Jan F. [VerfasserIn]   i
 Henon, Hilde [VerfasserIn]   i
 Dell’Acqua, Maria Luisa [VerfasserIn]   i
 Strambo, Davide [VerfasserIn]   i
 Stolp, Jeffrey [VerfasserIn]   i
 Heldner, Mirjam R. [VerfasserIn]   i
 Grisendi, Ilaria [VerfasserIn]   i
 Jovanovic, Dejana R. [VerfasserIn]   i
 Bejot, Yannick [VerfasserIn]   i
 Pezzini, Alessandro [VerfasserIn]   i
 Leker, Ronen R. [VerfasserIn]   i
 Kägi, Georg [VerfasserIn]   i
 Wegener, Susanne [VerfasserIn]   i
 Cereda, Carlo W. [VerfasserIn]   i
 Lindgren, Erik [VerfasserIn]   i
 Ntaios, George [VerfasserIn]   i
 Piot, Ines [VerfasserIn]   i
 Polymeris, Alexandros A. [VerfasserIn]   i
 Lyrer, Philippe A. [VerfasserIn]   i
 Räty, Silja [VerfasserIn]   i
 Sibolt, Gerli [VerfasserIn]   i
 Tiainen, Marjaana [VerfasserIn]   i
 Heyse, Miriam [VerfasserIn]   i
 Erdur, Hebun [VerfasserIn]   i
 Kaaouana, Olfa [VerfasserIn]   i
 Padjen, Visnja [VerfasserIn]   i
 Zedde, Marialuisa [VerfasserIn]   i
 Arnold, Marcel [VerfasserIn]   i
 Nederkoorn, Paul J. [VerfasserIn]   i
 Michel, Patrik [VerfasserIn]   i
 Bigliardi, Guido [VerfasserIn]   i
 Zini, Andrea [VerfasserIn]   i
 Cordonnier, Charlotte [VerfasserIn]   i
 Nolte, Christian H. [VerfasserIn]   i
 Ringleb, Peter A. [VerfasserIn]   i
 Curtze, Sami [VerfasserIn]   i
 Engelter, Stefan T. [VerfasserIn]   i
 Gensicke, Henrik [VerfasserIn]   i
Titel:Intravenous thrombolysis in patients with ischemic stroke aged ≥90 years
Titelzusatz:a cohort study from the TRISP Collaboration
Verf.angabe:Valerian L. Altersberger, Norman Rusche, Nicolas Martinez-Majander, Christian Hametner, Jan F. Scheitz, Hilde Henon, Maria Luisa Dell’Acqua, Davide Strambo, Jeffrey Stolp, Mirjam R. Heldner, Ilaria Grisendi, Dejana R. Jovanovic, Yannick Bejot, Alessandro Pezzini, Ronen R. Leker, Georg Kägi, Susanne Wegener, Carlo W. Cereda, Erik Lindgren, George Ntaios, Ines Piot, Alexandros A. Polymeris, Philippe A. Lyrer, Silja Räty, Gerli Sibolt, Marjaana Tiainen, Miriam Heyse, Hebun Erdur, Olfa Kaaouana, Visnja Padjen, Marialuisa Zedde, Marcel Arnold, Paul J. Nederkoorn, Patrik Michel, Guido Bigliardi, Andrea Zini, Charlotte Cordonnier, Christian H. Nolte, Peter A. Ringleb, Sami Curtze, Stefan T. Engelter, Henrik Gensicke, and for the Thrombolysis in Stroke Patients (TRISP) Collaborators
E-Jahr:2022
Jahr:14 Oct 2022
Umfang:7 S.
Fussnoten:Gesehen am 23.03.2023
Titel Quelle:Enthalten in: Stroke
Ort Quelle:New York, NY : Association, 1970
Jahr Quelle:2022
Band/Heft Quelle:53(2022), 12 vom: Okt., Seite 3557-3563
ISSN Quelle:1524-4628
Abstract:Background: - - The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely influence individual IVT treatment decisions. Using data from a large IVT registry, we aimed to provide more evidence on safety of IVT in the very elderly. - - Methods: - - In this prospective multicenter study from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry, we compared patients ≥90 years with those <90 years using symptomatic intracranial hemorrhage (ECASS [European Cooperative Acute Stroke Study]-II criteria), death, and poor functional outcome in survivors (modified Rankin Scale score 3-5 for patients with prestroke modified Rankin Scale score ≤2 and modified Rankin Scale score 4-5 for patients prestroke modified Rankin Scale ≥3) at 3 months as outcomes. We calculated adjusted odds ratio with 95% CI using logistic regression models. - - Results: - - Of 16 974 eligible patients, 976 (5.7%) were ≥90 years. Patients ≥90 years had higher median National Institutes of Health Stroke Scale on admission (12 versus 8) and were more often dependent prior to the index stroke (prestroke modified Rankin Scale score of ≥3; 45.2% versus 7.4%). Occurrence of symptomatic intracranial hemorrhage (5.7% versus 4.4%, odds ratioadjusted 1.14 [0.83-1.57]) did not differ significantly between both groups. However, the probability of death (odds ratioadjusted 3.77 [3.14-4.53]) and poor functional outcome (odds ratioadjusted 2.63 [2.13-3.25]) was higher in patients aged ≥90 years. Results for the sample of centenarians (n=21) were similar. - - Conclusions: - - The probability of symptomatic intracranial hemorrhage after IVT in very elderly patients with stroke did not exceed that of their younger counterparts. The higher probability of death and poor functional outcome during follow-up in the very elderly seems not to be related to IVT treatment. Very high age itself should not be a reason to withhold IVT.
DOI:doi:10.1161/STROKEAHA.122.039426
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1161/STROKEAHA.122.039426
 Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.039426
 DOI: https://doi.org/10.1161/STROKEAHA.122.039426
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:aged
 intracranial hemorrhage
 ischemic stroke
 registries
 survivors
K10plus-PPN:1839907096
Verknüpfungen:→ Zeitschrift

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