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Verfasst von:Hedtke, Maren [VerfasserIn]   i
 Pessoa Rejas, Rodrigo [VerfasserIn]   i
 Froelich, Matthias F. [VerfasserIn]   i
 Ast, Volker [VerfasserIn]   i
 Duda, Angelika [VerfasserIn]   i
 Mirbach, Laura [VerfasserIn]   i
 Costina, Victor [VerfasserIn]   i
 Martens, Uwe Marc [VerfasserIn]   i
 Hofheinz, Ralf-Dieter [VerfasserIn]   i
 Neumaier, Michael [VerfasserIn]   i
 Haselmann, Verena [VerfasserIn]   i
Titel:Liquid profiling of circulating tumor DNA in colorectal cancer
Titelzusatz:steps needed to achieve its full clinical value as standard care
Verf.angabe:Maren Hedtke, Rodrigo Pessoa Rejas, Matthias F. Froelich, Volker Ast, Angelika Duda, Laura Mirbach, Victor Costina, Uwe M. Martens, Ralf-Dieter Hofheinz, Michael Neumaier and Verena Haselmann
Jahr:2022
Umfang:15 S.
Fussnoten:Available online 20 December 2021 ; Gesehen am 23.03.2023
Titel Quelle:Enthalten in: Molecular oncology
Ort Quelle:Hoboken, NJ : John Wiley & Sons, Inc., 2007
Jahr Quelle:2022
Band/Heft Quelle:16(2022), 10, Seite 2042-2056
ISSN Quelle:1878-0261
Abstract:The analysis of circulating tumor DNA (ctDNA) is at the threshold of implementation into standard care for colorectal cancer (CRC) patients. However, data about the clinical utility of liquid profiling (LP), its acceptance by clinicians, and its integration into clinical workflows in real-world settings remain limited. Here, LP tests requested as part of routine care since 2016 were retrospectively evaluated. Results show restrained request behavior that improved moderately over time, as well as reliable diagnostic performance comparable to translational studies, with an overall agreement of 91.7%. Extremely low ctDNA levels at < 0.1% in over 20% of cases, a high frequency of concomitant driver mutations (in up to 14% of cases), and ctDNA levels reflecting the clinical course of disease were revealed. However, certain limitations hampering successful translation of ctDNA into clinical practice were uncovered, including the lack of clinically relevant ctDNA thresholds, appropriate time points of LP requests, and integrative evaluation of ctDNA, imaging, and clinical findings. In conclusion, these results highlight the potential clinical value of LP for CRC patient management and demonstrate issues that need to be addressed for successful long-term implementation in clinical workflows.
DOI:doi:10.1002/1878-0261.13156
URL:kostenfrei: Volltext: https://doi.org/10.1002/1878-0261.13156
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.13156
 DOI: https://doi.org/10.1002/1878-0261.13156
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:colorectal cancer
 ctDNA
 liquid biopsy
 liquid profiling
 real-world
K10plus-PPN:183989895X
Verknüpfungen:→ Zeitschrift
 
 
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