Prediction of cardiac events with non-contrast magnetic resonance feature tracking in patients with ischaemic cardiomyopathy

• Verfasst von: Overhoff, Daniel [VerfasserIn]
• Verfasst von: Ansari, Uzair [VerfasserIn]
• Verfasst von: Hohneck, Anna [VerfasserIn]
• Verfasst von: Tueluemen, Erol [VerfasserIn]
• Verfasst von: Rudic, Boris [VerfasserIn]
• Verfasst von: Kuschyk, Jürgen [VerfasserIn]
• Verfasst von: Loßnitzer, Dirk [VerfasserIn]
• Verfasst von: Baumann, Stefan [VerfasserIn]
• Verfasst von: Froelich, Matthias F. [VerfasserIn]
• Verfasst von: Waldeck, Stephan [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Papavassiliu, Theano [VerfasserIn]
• Titel: Prediction of cardiac events with non-contrast magnetic resonance feature tracking in patients with ischaemic cardiomyopathy
• Verf.angabe: Daniel Overhoff, Uzair Ansari, Anna Hohneck, Erol Tülümen, Boris Rudic, Jürgen Kuschyk, Dirk Lossnitzer, Stefan Baumann, Matthias F. Froelich, Stephan Waldeck, Ibrahim Akin, Martin Borggrefe, Stefan O. Schoenberg and Theano Papavassiliu
• Jahr: 2022
• Umfang: 11 S.
• Fussnoten: Published online 24 November 2021 ; Gesehen am 24.03.2023
• Titel Quelle: Enthalten in: European Society of CardiologyESC heart failure
• Ort Quelle: Chichester : Wiley, 2014
• Jahr Quelle: 2022
• Band/Heft Quelle: 9(2022), 1, Seite 574-584
• ISSN Quelle: 2055-5822
• DOI: doi:10.1002/ehf2.13712
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Ejection fraction
• Sach-SW: Feature tracking
• Sach-SW: Implantable cardioverter defibrillator
• Sach-SW: Ischaemic cardiomyopathy
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Non-contrast media
• Sach-SW: Strain
• Sach-SW: Sudden cardiac death
• Sach-SW: Ventricular tachycardia
• K10plus-PPN: 1840001100
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Aims The aim of this study was to evaluate the prognostic value of feature tracking (FT) derived cardiac magnetic resonance (CMR) strain parameters of the left ventricle (LV)/right ventricle (RV) in ischaemic cardiomyopathy (ICM) patients treated with an implantable cardioverter-defibrillator (ICD). Current guidelines suggest a LV-ejection fraction ≤35% as major criterion for ICD implantation in ICM, but this is a poor predictor for arrhythmic events. Supplementary parameters are missing. Methods and results Ischaemic cardiomyopathy patients (n = 242), who underwent CMR imaging prior to primary and secondary implantation of ICD, were classified depending on EF ≤ 35% (n = 188) or >35% (n = 54). FT parameters were derived from steady-state free precession cine views using dedicated software. The primary endpoint was a composite of cardiovascular mortality (CVM) and/or appropriate ICD therapy. There were no significant differences in FT-function or LV-/RV-function parameters in patients with an EF ≤ 35% correlating to the primary endpoint. In patients with EF > 35%, standard CMR functional parameters, such as LV-EF, did not reveal significant differences. However, significant differences in most FT parameters correlating to the primary endpoint were observed in this subgroup. LV-GLS (left ventricular-global longitudinal strain) and RV-GRS (right ventricular-global radial strain) revealed the best diagnostic performance in ROC curve analysis. The combination of LV-GLS and RV-GRS showed a sensitivity of 85% and a specificity of 76% for the prediction of future events. Conclusions The impact of FT derived measurements in the risk stratification of patients with ICM depends on LV function. The combination of LV-GLS/RV-GRS seems to be a predictor of cardiovascular mortality and/or appropriate ICD therapy in patients with EF > 35%.