Notch signaling in acute inflammation and sepsis

• Verfasst von: Gallenstein, Nadia [VerfasserIn]
• Verfasst von: Tichy, Lucas [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Schenz, Judith [VerfasserIn]
• Titel: Notch signaling in acute inflammation and sepsis
• Verf.angabe: Nadia Gallenstein, Lucas Tichy, Markus Alexander Weigand and Judith Schenz
• E-Jahr: 2023
• Jahr: 9 February 2023
• Umfang: 26 S.
• Fussnoten: Gesehen am 24.03.2023
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2023
• Band/Heft Quelle: 24(2023), 4, Artikel-ID 3458, Seite 1-26
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms24043458
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: DLL
• Sach-SW: immune cells
• Sach-SW: immune response
• Sach-SW: infection
• Sach-SW: inflammation
• Sach-SW: Jagged
• Sach-SW: Notch
• Sach-SW: sepsis
• Sach-SW: SIRS
• Sach-SW: therapy
• K10plus-PPN: 1840010940

Abstract

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and homeostasis of immune cells. Besides, this pathway is also directly involved in the transmission of immune signals. Notch signaling per se does not have a clear pro- or anti-inflammatory effect, but rather its impact is highly dependent on the immune cell type and the cellular environment, modulating several inflammatory conditions including sepsis, and therefore significantly impacts the course of disease. In this review, we will discuss the contribution of Notch signaling on the clinical picture of systemic inflammatory diseases, especially sepsis. Specifically, we will review its role during immune cell development and its contribution to the modulation of organ-specific immune responses. Finally, we will evaluate to what extent manipulation of the Notch signaling pathway could be a future therapeutic strategy.