Comparing the influence of surgical and conservative therapy on quality of life in patients with early-stage medication-related Osteonecrosis of the jaw - a prospective longitudinal study

• Verfasst von: Rückschloß, Thomas [VerfasserIn]
• Verfasst von: Smielowski, Maximilian [VerfasserIn]
• Verfasst von: Moratin, Julius [VerfasserIn]
• Verfasst von: Schnug, Gregor [VerfasserIn]
• Verfasst von: Appel, Maximilian [VerfasserIn]
• Verfasst von: Münch, Philipp [VerfasserIn]
• Verfasst von: Bleymehl, Moritz [VerfasserIn]
• Verfasst von: Zittel, Sven [VerfasserIn]
• Verfasst von: Engel, Michael [VerfasserIn]
• Verfasst von: Hoffmann, Jürgen [VerfasserIn]
• Verfasst von: Ristow, Oliver [VerfasserIn]
• Titel: Comparing the influence of surgical and conservative therapy on quality of life in patients with early-stage medication-related Osteonecrosis of the jaw - a prospective longitudinal study
• Verf.angabe: Thomas Rückschloß, Maximilian Smielowski, Julius Moratin, Gregor Schnug, Maximilian Appel, Philipp Muench, Moritz Bleymehl, Sven Zittel, Michael Engel, Jürgen Hoffmann and Oliver Ristow
• E-Jahr: 2023
• Jahr: 31 January 2023
• Umfang: 11 S.
• Fussnoten: Gesehen am 24.03.2023
• Titel Quelle: Enthalten in: Medicina
• Ort Quelle: Kaunas : Kaunas Univ. of Medicine, 2001
• Jahr Quelle: 2023
• Band/Heft Quelle: 59(2023), 2 vom: Jan., Artikel-ID 277, Seite 1-11
• ISSN Quelle: 1648-9144
• DOI: doi:10.3390/medicina59020277
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ARONJ
• Sach-SW: management
• Sach-SW: MRONJ
• Sach-SW: QHIP
• Sach-SW: QLQ-C30
• Sach-SW: quality of life
• Sach-SW: therapy
• K10plus-PPN: 1840019093

Abstract

Background and Objectives: The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on general health-related (QoL) and oral health-related quality of life (OHRQoL) in patients suffering from AAOMS stage I MRONJ. Materials and Methods: In the course of this prospective clinical study, QoL and OHRQoL using QLQ-C30 and QHIP G14 questionnaire were longitudinally assessed in N = 174 prospectively enrolled patients with indication of treatment of MRONJ stage I over a period of 12 months. Patients received conservative or surgical treatment. The measurement time points were preoperatively (T0), 12 weeks (T1), 6 months (T2) and 1 year after operation (T3). Results: For OHRQoL, no significant (p > 0.05) differences were found between both treatment groups for all timepoints (T0-T3). In the surgical treatment group, OHIP scores of T1, T2 and T3 were significantly lower than baseline measures (T0) (T0-T1 (2.99, p = 0.024), T0-T2 (5.20, p < 0.001), T0-T3 (7.44, p < 0.001)). For conservative treatment group OHIP, scores of T2 and T3 were significantly lower than baseline measures (T0) (T0-T2 (9.09, p = 0.013), T0-T3 (12.79, p < 0.001)). There was no statistically significant effect of time on QLQ-C30 scores in both groups (surgical treatment: F(3, 174) = 1.542, p < 0.205, partial η2 = 0.026; conservative treatment: F(3, 30) = 0.528, p = 0.667, partial η2 = 0.050). QLQ-C30 scores turned out to be significantly lower in the non-surgical group at T1 (p = 0.036) and T3 (p = 0.047) compared to the surgical treatment group. Conclusions: Surgical and conservative treatment of MRONJ stage I significantly improves patients’ OHRQoL. Surgical treatment is superior to conservative treatment of MRONJ stage I regarding general QoL. Therefore, surgical treatment of MRONJ stage I should not be omitted for QoL reasons.