Determinants of specificity at the protein-lipid interface in membranes

• Verfasst von: Ernst, Andreas M. [VerfasserIn]
• Verfasst von: Contreras, F. Xabier [VerfasserIn]
• Verfasst von: Brügger, Britta [VerfasserIn]
• Verfasst von: Wieland, Felix T. [VerfasserIn]
• Titel: Determinants of specificity at the protein-lipid interface in membranes
• Verf.angabe: Andreas M. Ernst, F. Xabier Contreras, Britta Brügger, Felix Wieland
• E-Jahr: 2010
• Jahr: 19 January 2010
• Umfang: 8 S.
• Fussnoten: Gesehen am 27.03.2023
• Titel Quelle: Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters
• Ort Quelle: Chichester : Wiley, 1968
• Jahr Quelle: 2010
• Band/Heft Quelle: 584(2010), 9 vom: Mai, Seite 1713-1720
• ISSN Quelle: 1873-3468
• DOI: doi:10.1016/j.febslet.2009.12.060
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Intra-membrane
• Sach-SW: Protein-lipid interaction
• K10plus-PPN: 1840147210

Abstract

The complexity of pro- and eukaryotic lipidomes is increasingly appreciated mainly owing to the advance of mass spectrometric methods. Biophysical approaches have revealed that the large number of lipid classes and molecular species detected have implications for the self-organizing potential of biological membranes, resulting in the formation of lateral heterogeneous phases. How membrane proteins are able to adapt specifically to their surrounding heterogeneous matrix, and whether this environment affects protein targeting and function, is therefore a matter of particular interest. Here, we review specific protein-lipid interactions, focusing on the molecular mechanisms that determine specificity at the protein-lipid interface, and on membrane proteins that require lipids as cofactors for their architecture and function.