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| Verfasst von: | Körber, Verena [VerfasserIn]  |
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| | Stainczyk, Sabine [VerfasserIn] |
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| | Kurilov, Roman [VerfasserIn] |
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| | Henrich, Kai-Oliver [VerfasserIn] |
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| | Hero, Barbara [VerfasserIn] |
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| | Brors, Benedikt [VerfasserIn] |
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| | Westermann, Frank [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| Titel: | Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome |
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| Verf.angabe: | Verena Körber, Sabine A. Stainczyk, Roma Kurilov, Kai-Oliver Henrich, Barbara Hero, Benedikt Brors, Frank Westermann, Thomas Höfer |
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| E-Jahr: | 2023 |
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| Jahr: | 27 March 2023 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 28.03.2023 |
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| Titel Quelle: | Enthalten in: Nature genetics |
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| Ort Quelle: | London : Macmillan Publishers Limited, part of Springer Nature, 1992 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 55(2023), 4, Seite 1-12 |
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| ISSN Quelle: | 1546-1718 |
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| Abstract: | Neuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from spontaneous regression to fatal disease. When these different tumors originate and how they evolve are not known. Here we quantify the somatic evolution of neuroblastoma by deep whole-genome sequencing, molecular clock analysis and population-genetic modeling in a comprehensive cohort covering all subtypes. We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as the first trimester of pregnancy. Neuroblastomas with favorable prognosis expand clonally after short evolution, whereas aggressive neuroblastomas show prolonged evolution during which they acquire telomere maintenance mechanisms. The initial aneuploidization events condition subsequent evolution, with aggressive neuroblastoma exhibiting early genomic instability. We find in the discovery cohort (n = 100), and validate in an independent cohort (n = 86), that the duration of evolution is an accurate predictor of outcome. Thus, insight into neuroblastoma evolution may prospectively guide treatment decisions. |
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| DOI: | doi:10.1038/s41588-023-01332-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41588-023-01332-y |
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| | Volltext: https://www.nature.com/articles/s41588-023-01332-y |
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| | DOI: https://doi.org/10.1038/s41588-023-01332-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Embryonal neoplasms |
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| | Population dynamics |
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| | Population genetics |
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| K10plus-PPN: | 1840276169 |
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| Verknüpfungen: | → Zeitschrift |
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Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome / Körber, Verena [VerfasserIn]; 27 March 2023 (Online-Ressource)
