Association of tumor volumetry with postoperative outcomes for cervical paraganglioma

• Verfasst von: Hoffmann-Wieker, Carola Marie [VerfasserIn]
• Verfasst von: Gomes dos Santos Ferreira Rebelo, Artur Luis [VerfasserIn]
• Verfasst von: Moll, Martin [VerfasserIn]
• Verfasst von: Ronellenfitsch, Ulrich [VerfasserIn]
• Verfasst von: Rengier, Fabian [VerfasserIn]
• Verfasst von: Erhart, Philipp [VerfasserIn]
• Verfasst von: Böckler, Dittmar [VerfasserIn]
• Verfasst von: Ukkat, Jörg [VerfasserIn]
• Titel: Association of tumor volumetry with postoperative outcomes for cervical paraganglioma
• Verf.angabe: Carola Marie Hoffmann-Wieker, Artur Rebelo, Martin Moll, Ulrich Ronellenfitsch, Fabian Rengier, Philipp Erhart, Dittmar Böckler and Jörg Ukkat
• E-Jahr: 2023
• Jahr: 15 February 2023
• Umfang: 9 S.
• Fussnoten: Gesehen am 28.03.2023
• Titel Quelle: Enthalten in: Diagnostics
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2023
• Band/Heft Quelle: 13(2023), 4 vom: Feb., Artikel-ID 744, Seite 1-9
• ISSN Quelle: 2075-4418
• DOI: doi:10.3390/diagnostics13040744
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: carotid body tumor
• Sach-SW: cervical paraganglioma
• Sach-SW: cranial nerve injury
• Sach-SW: preoperative imaging
• Sach-SW: volumetry
• K10plus-PPN: 1840279605

Abstract

Objectives: To analyze the association of tumor volume with outcome after surgery for cervical paraganglioma. Materials and Methods: This retrospective study included consecutive patients undergoing surgery for cervical paraganglioma from 2009-2020. Outcomes were 30-day morbidity, mortality, cranial nerve injury, and stroke. Preoperative CT/MRI was used for tumor volumetry. An association between the volume and the outcomes was explored in univariate and multivariable analyses. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated. The study was conducted and reported according to the STROBE statement. Results: Volumetry was successful in 37/47 (78.8%) of included patients. A 30-day morbidity occurred in 13/47 (27.6%) patients with no mortality. Fifteen cranial nerve lesions occurred in eleven patients. The mean tumor volume was 6.92 cm3 in patients without and 15.89 cm3 in patients with complications (p = 0.035) and 7.64 cm3 in patients without and 16.28 cm3 in patients with cranial nerve injury (p = 0.05). Neither the volume nor Shamblin grade was significantly associated with complications on multivariable analysis. The AUC was 0.691, indicating a poor to fair performance of volumetry in predicting postoperative complications. Conclusions: Surgery for cervical paraganglioma bears a relevant morbidity with a particular risk of cranial nerve lesions. Tumor volume is associated with morbidity, and MRI/CT volumetry can be used for risk stratification.