| |  Online-Ressource |
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| Verfasst von: | Mann, Jake P. [VerfasserIn]  |
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| | Lenz, Dominic [VerfasserIn] |
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| | Stamataki, Zania [VerfasserIn] |
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| | Kelly, Deirdre [VerfasserIn] |
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| Titel: | Common mechanisms in pediatric acute liver failure |
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| Verf.angabe: | Jake P. Mann, Dominic Lenz, Zania Stamataki, and Deirdre Kelly |
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| E-Jahr: | 2023 |
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| Jahr: | 15 February 2023 |
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| Umfang: | 16 S. |
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| Fussnoten: | Online verfügbar 7 Dezember 2022, Artikelversion 15 Februar 2023 ; Gesehen am 28.03.2023 |
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| Titel Quelle: | Enthalten in: Trends in molecular medicine |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2001 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 29(2023), 3, Seite 228-240 |
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| ISSN Quelle: | 1471-499X |
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| Abstract: | Acute liver failure (ALF) is a rare but potentially fatal disease in children. The etiology is multifactorial, including infection, autoimmune, and genetic disorders, as well as indeterminate hepatitis, which has a higher requirement for liver transplantation. Activation of the innate and adaptive immune systems leads to hepatocyte-specific injury which is mitigated by T regulatory cell activation. Recovery of the native liver depends on activation of apoptotic and regenerative pathways, including the integrated stress response (ISR; e.g., PERK), p53, and HNF4α. Loss-of-function mutations in these pathways cause recurrent ALF in response to non-hepatotropic viruses. Deeper understanding of these mechanisms will lead to improved diagnosis, management, and outcomes for pediatric ALF. |
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| DOI: | doi:10.1016/j.molmed.2022.11.006 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.molmed.2022.11.006 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1471491422002994 |
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| | DOI: https://doi.org/10.1016/j.molmed.2022.11.006 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | acute liver failure |
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| | adenovirus |
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| | hepatocyte regeneration |
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| | integrated stress response |
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| K10plus-PPN: | 1840306203 |
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| Verknüpfungen: | → Zeitschrift |
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Common mechanisms in pediatric acute liver failure / Mann, Jake P. [VerfasserIn]; 15 February 2023 (Online-Ressource)
