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| Verfasst von: | Campos, Benito [VerfasserIn]  |
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| | Wan, Feng [VerfasserIn] |
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| | Farhadi, Mohammad Reza [VerfasserIn] |
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| | Ernst, Aurélie [VerfasserIn] |
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| | Zeppernick, Felix [VerfasserIn] |
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| | Tagscherer, Katrin [VerfasserIn] |
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| | Ahmadi, Rezvan [VerfasserIn] |
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| | Lohr, Jennifer [VerfasserIn] |
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| | Dictus, Christine [VerfasserIn] |
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| | Gdynia, Georg [VerfasserIn] |
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| | Combs, Stephanie [VerfasserIn] |
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| | Goidts, Violaine [VerfasserIn] |
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| | Helmke, Burkhard Maria [VerfasserIn] |
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| | Eckstein, Volker [VerfasserIn] |
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| | Roth, Wilfried [VerfasserIn] |
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| | Beckhove, Philipp [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Unterberg, Andreas [VerfasserIn] |
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| | Radlwimmer, Bernhard [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| Titel: | Differentiation therapy exerts antitumor effects on stem-like glioma cells |
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| Verf.angabe: | Benito Campos, Feng Wan, Mohammad Farhadi, Aurélie Ernst, Felix Zeppernick, Katrin E. Tagscherer, Rezvan Ahmadi, Jennifer Lohr, Christine Dictus, Georg Gdynia, Stephanie E. Combs, Violaine Goidts, Burkhard M. Helmke, Volker Eckstein, Wilfried Roth, Philipp Beckhove, Peter Lichter, Andreas Unterberg, Bernhard Radlwimmer, and Christel Herold-Mende |
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| E-Jahr: | 2010 |
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| Jahr: | May 13 2010 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 29.03.2023 |
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| Titel Quelle: | Enthalten in: Clinical cancer research |
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| Ort Quelle: | Philadelphia, Pa. [u.a.] : AACR, 1995 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 16(2010), 10, Seite 2715-2728 |
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| ISSN Quelle: | 1557-3265 |
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| Abstract: | Purpose: Stem-like tumor cells comprise a highly tumorigenic and therapy-resistant tumor subpopulation, which is believed to substantially influence tumor initiation and therapy resistance in glioma. Currently, therapeutic, drug-induced differentiation is considered as a promising approach to eradicate this tumor-driving cell population; retinoic acid is well known as a potent modulator of differentiation and proliferation in normal stem cells. In glioma, knowledge about the efficacy of retinoic acid-induced differentiation to target the stem-like tumor cell pool could have therapeutic implications.Experimental Design: Stem-like glioma cells (SLGC) were differentiated with all-trans retinoic acid-containing medium to study the effect of differentiation on angiogenesis, invasive growth, as well as radioresistance and chemoresistance of SLGCs. In vivo effects were studied using live microscopy in a cranial window model.Results: Our data suggest that in vitro differentiation of SLGCs induces therapy-sensitizing effects, impairs the secretion of angiogenic cytokines, and disrupts SLGCs motility. Further, ex vivo differentiation reduces tumorigenicity of SLGCs. Finally, we show that all-trans retinoic acid treatment alone can induce antitumor effects in vivo.Conclusions: Altogether, these results highlight the potential of differentiation treatment to target the stem-like cell population in glioblastoma. Clin Cancer Res; 16(10); 2715-28. ©2010 AACR. |
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| DOI: | doi:10.1158/1078-0432.CCR-09-1800 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/1078-0432.CCR-09-1800 |
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| | DOI: https://doi.org/10.1158/1078-0432.CCR-09-1800 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1840448636 |
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| Verknüpfungen: | → Zeitschrift |
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Differentiation therapy exerts antitumor effects on stem-like glioma cells / Campos, Benito [VerfasserIn]; May 13 2010 (Online-Ressource)
