| |  Online-Ressource |
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| Verfasst von: | Fortner, Andra [VerfasserIn]  |
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| | Chera, Alexandra [VerfasserIn] |
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| | Tanca, Antoanela [VerfasserIn] |
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| | Bucur, Octavian [VerfasserIn] |
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| Titel: | Apoptosis regulation by the tyrosine-protein kinase CSK |
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| Verf.angabe: | Andra Fortner, Alexandra Chera, Antoanela Tanca and Octavian Bucur |
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| E-Jahr: | 2022 |
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| Jahr: | 12 December 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 29.03.2023 |
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| Titel Quelle: | Enthalten in: Frontiers in cell and developmental biology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), Artikel-ID 1078180, Seite 1-14 |
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| ISSN Quelle: | 2296-634X |
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| Abstract: | C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms of action, regulation and functions is still at an early stage, most of CSK's known actions and functions being mediated by the negative regulation of the SRC family of tyrosine kinases (SFKs) through phosphorylation. As SFKs play a vital role in apoptosis, cell proliferation and survival regulation, SFK inhibition by CSK has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by SFKs, such as the MAPK/ERK, STAT3 and PI3K/AKT signaling pathways. Abnormal functioning of CSK and SFK activation can lead to diseases such as cancer, cardiovascular and neurological manifestations. This review describes apoptosis regulation by CSK, CSK inhibition of the SFKs and further explores the clinical relevance of CSK in important pathologies, such as cancer, autoimmune, autoinflammatory, neurologic diseases, hypertension and HIV/AIDS. |
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| DOI: | doi:10.3389/fcell.2022.1078180 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3389/fcell.2022.1078180 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fcell.2022.1078180/full |
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| | DOI: https://doi.org/10.3389/fcell.2022.1078180 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | c-terminal-src |
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| | colon-cancer |
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| | Csk |
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| | elongation-factor 2 |
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| | family kinases |
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| | hiv-1 nef |
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| | in-vivo |
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| | MAPK pathway |
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| | negative regulators |
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| | phosphorylation |
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| | PI3K-Akt pathway |
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| | sfk |
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| | src |
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| | Src kinases |
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| | t-cell-activation |
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| | tyrosine-protein kinase CSK |
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| | virus type-1 nef |
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| K10plus-PPN: | 1840482540 |
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| Verknüpfungen: | → Zeitschrift |
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Apoptosis regulation by the tyrosine-protein kinase CSK / Fortner, Andra [VerfasserIn]; 12 December 2022 (Online-Ressource)
