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| Verfasst von: | Groth, Christopher [VerfasserIn]  |
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| | Weber, Rebekka [VerfasserIn] |
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| | Lasser, Samantha [VerfasserIn] |
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| | Özbay Kurt, Feyza Gül [VerfasserIn] |
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| | Kurzay, Annina [VerfasserIn] |
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| | Petrova, Vera [VerfasserIn] |
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| | Altevogt, Peter [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| Titel: | Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization |
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| Verf.angabe: | Christopher Groth, Rebekka Weber, Samantha Lasser, Feyza Gül Özbay, Annina Kurzay, Vera Petrova, Peter Altevogt, Jochen Utikal, Viktor Umansky |
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| Jahr: | 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 30.03.2023 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 149(2021), 9, Seite 1628-1638 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | Myeloid-derived suppressor cells (MDSC) represent a highly immunosuppressive population that expands in tumor bearing hosts and inhibits both T and NK cell antitumor effector functions. Among MDSC subpopulations, the polymorphonuclear (PMN) one is gaining increasing interest since it is a predominant MDSC subset in most cancer entities and inherits unique properties to facilitate metastatic spread. In addition, further improvement in distinguishing PMN-MDSC from neutrophils has contributed to the design of novel therapeutic approaches. In this review, we summarize the current view on the origin of PMN-MDSC and their relation to classical neutrophils. Furthermore, we outline the metastasis promoting features of these cells and promising strategies of their targeting to improve the efficacy of cancer immunotherapy. |
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| DOI: | doi:10.1002/ijc.33731 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1002/ijc.33731 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33731 |
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| | DOI: https://doi.org/10.1002/ijc.33731 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | immunosuppression |
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| | immunotherapy |
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| | metastasis |
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| | neutrophils |
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| | PMN-MDSC |
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| K10plus-PPN: | 1840611391 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization / Groth, Christopher [VerfasserIn]; 2021 (Online-Ressource)
