| |  Online-Ressource |
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| Verfasst von: | Liu, Yibin [VerfasserIn]  |
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| | Keib, Anna [VerfasserIn] |
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| | Neuber, Brigitte [VerfasserIn] |
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| | Wang, Lei [VerfasserIn] |
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| | Riemer, Angelika [VerfasserIn] |
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| | Bonsack, Maria [VerfasserIn] |
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| | Hückelhoven-Krauss, Angela [VerfasserIn] |
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| | Schmitt, Anita [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| Titel: | Definition and characterization of SOX11-derived T cell epitopes towards immunotherapy of glioma |
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| Verf.angabe: | Yibin Liu, Anna Keib, Brigitte Neuber, Lei Wang, Angelika B. Riemer, Maria Bonsack, Angela Hückelhoven-Krauss, Anita Schmitt, Carsten Müller-Tidow and Michael Schmitt |
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| E-Jahr: | 2023 |
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| Jahr: | 18 January 2023 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 31.03.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 3, Artikel-ID 1943, Seite 1-18 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The transcription factor SOX11 is a tumor-associated antigen with low expression in normal cells, but overexpression in glioblastoma (GBM). So far, conventional surgery, chemotherapy, and radiotherapy have not substantially improved the dismal prognosis of relapsed/refractory GBM patients. Immunotherapy is considered a promising strategy against GBM, but there is a fervent need for better immunotargets in GBM. To this end, we performed an in silico prediction study on SOX11, which primarily yielded ten promising HLA-A*0201-restricted peptides derived from SOX11. We defined a novel peptide FMACSPVAL, which had the highest score according to in silico prediction (6.02 nM by NetMHC-4.0) and showed an exquisite binding affinity to the HLA-A*0201 molecule in the peptide-binding assays. In the IFN-γ ELISPOT assays, FMACSPVAL demonstrated a high efficiency for generating SOX11-specific CD8+ T cells. Nine out of thirty-two healthy donors showed a positive response to SOX11, as assessed by the ELISPOT assays. Therefore, this novel antigen peptide epitope seems to be promising as a target for T cell-based immunotherapy in GBM. The adoptive transfer of in vitro elicited SOX11-specific CD8+ T cells constitutes a potential approach for the treatment of GBM patients. |
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| DOI: | doi:10.3390/ijms24031943 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms24031943 |
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| | Volltext: https://www.mdpi.com/1422-0067/24/3/1943 |
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| | DOI: https://doi.org/10.3390/ijms24031943 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | glioma |
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| | HLA-A*0201 |
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| | immunotherapy |
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| | SOX11 |
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| | tumor-associated antigen |
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| K10plus-PPN: | 1840923490 |
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| Verknüpfungen: | → Zeitschrift |
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Definition and characterization of SOX11-derived T cell epitopes towards immunotherapy of glioma / Liu, Yibin [VerfasserIn]; 18 January 2023 (Online-Ressource)
