| |  Online-Ressource |
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| Verfasst von: | Schossig, Paul [VerfasserIn]  |
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| | Coskun, Ebru [VerfasserIn] |
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| | Arsenic, Ruza [VerfasserIn] |
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| | Horst, David [VerfasserIn] |
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| | Sehouli, Jalid [VerfasserIn] |
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| | Bergmann, Eva [VerfasserIn] |
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| | Andresen, Nadine [VerfasserIn] |
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| | Sigler, Christian [VerfasserIn] |
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| | Busse, Antonia [VerfasserIn] |
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| | Keller, Ulrich [VerfasserIn] |
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| | Ochsenreither, Sebastian [VerfasserIn] |
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| Titel: | Target selection for T-cell therapy in epithelial ovarian cancer |
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| Titelzusatz: | systematic prioritization of self-antigens |
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| Verf.angabe: | Paul Schossig, Ebru Coskun, Ruza Arsenic, David Horst, Jalid Sehouli, Eva Bergmann, Nadine Andresen, Christian Sigler, Antonia Busse, Ulrich Keller and Sebastian Ochsenreither |
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| E-Jahr: | 2023 |
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| Jahr: | 24 January 2023 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 31.03.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 3 vom: Jan., Artikel-ID 2292, Seite 1-22 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Adoptive T cell-receptor therapy (ACT) could represent a promising approach in the targeted treatment of epithelial ovarian cancer (EOC). However, the identification of suitable tumor-associated antigens (TAAs) as targets is challenging. We identified and prioritized TAAs for ACT and other immunotherapeutic interventions in EOC. A comprehensive list of pre-described TAAs was created and candidates were prioritized, using predefined weighted criteria. Highly ranked TAAs were immunohistochemically stained in a tissue microarray of 58 EOC samples to identify associations of TAA expression with grade, stage, response to platinum, and prognosis. Preselection based on expression data resulted in 38 TAAs, which were prioritized. Along with already published Cyclin A1, the TAAs KIF20A, CT45, and LY6K emerged as most promising targets, with high expression in EOC samples and several identified peptides in ligandome analysis. Expression of these TAAs showed prognostic relevance independent of molecular subtypes. By using a systematic vetting algorithm, we identified KIF20A, CT45, and LY6K to be promising candidates for immunotherapy in EOC. Results are supported by IHC and HLA-ligandome data. The described method might be helpful for the prioritization of TAAs in other tumor entities. |
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| DOI: | doi:10.3390/ijms24032292 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms24032292 |
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| | Volltext: https://www.mdpi.com/1422-0067/24/3/2292 |
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| | DOI: https://doi.org/10.3390/ijms24032292 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CT45 |
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| | Cyclin A1 |
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| | cytotoxic T lymphocytes |
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| | immunotherapy |
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| | KIF20A |
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| | LY6K |
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| | ovarian cancer |
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| | tumor associated antigen |
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| K10plus-PPN: | 1840953209 |
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| Verknüpfungen: | → Zeitschrift |
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Target selection for T-cell therapy in epithelial ovarian cancer / Schossig, Paul [VerfasserIn]; 24 January 2023 (Online-Ressource)
