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| Verfasst von: | Thatikonda, Venu [VerfasserIn]  |
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| | Islam, S. M. Ashiqul [VerfasserIn] |
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| | Autry, Robert J. [VerfasserIn] |
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| | Jones, Barbara Christine [VerfasserIn] |
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| | Gröbner, Susanne N. [VerfasserIn] |
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| | Warsow, Gregor [VerfasserIn] |
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| | Hutter, Barbara [VerfasserIn] |
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| | Hübschmann, Daniel [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Blattner-Johnson, Mirjam [VerfasserIn] |
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| | Jones, David T. W. [VerfasserIn] |
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| | Alexandrov, Ludmil B. [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Jäger, Natalie [VerfasserIn] |
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| Titel: | Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers |
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| Verf.angabe: | Venu Thatikonda, S.M. Ashiqul Islam, Robert J. Autry, Barbara C. Jones, Susanne N. Gröbner, Gregor Warsow, Barbara Hutter, Daniel Huebschmann, Stefan Fröhling, Marcel Kool, Mirjam Blattner-Johnson, David T.W. Jones, Ludmil B. Alexandrov, Stefan M. Pfister & Natalie Jäger |
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| E-Jahr: | 2023 |
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| Jahr: | 26 January 2023 |
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| Umfang: | 28 S. |
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| Fussnoten: | Gesehen am 04.04.2023 |
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| Titel Quelle: | Enthalten in: Nature cancer |
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| Ort Quelle: | London : Nature Research, 2020 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 4(2023), 2 vom: Jan., Seite 276-289 |
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| ISSN Quelle: | 2662-1347 |
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| Abstract: | Analysis of mutational signatures can reveal underlying molecular mechanisms of the processes that have imprinted the somatic mutations found in cancer genomes. Here, we analyze single base substitutions and small insertions and deletions in pediatric cancers encompassing 785 whole-genome sequenced tumors from 27 molecularly defined cancer subtypes. We identified only a small number of mutational signatures active in pediatric cancers, compared with previously analyzed adult cancers. Further, we report a significant difference in the proportion of pediatric tumors showing homologous recombination repair defect signatures compared with previous analyses. In pediatric leukemias, we identified an indel signature, not previously reported, characterized by long insertions in nonrepeat regions, affecting mainly intronic and intergenic regions, but also exons of known cancer genes. We provide a systematic overview of COSMIC v.3 mutational signatures active across pediatric cancers, which is highly relevant for understanding tumor biology and enabling future research in defining biomarkers of treatment response. |
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| DOI: | doi:10.1038/s43018-022-00509-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s43018-022-00509-4 |
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| | Volltext: https://www.nature.com/articles/s43018-022-00509-4 |
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| | DOI: https://doi.org/10.1038/s43018-022-00509-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer |
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| | Cancer genomics |
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| | Functional clustering |
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| | Paediatric cancer |
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| K10plus-PPN: | 184116934X |
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| Verknüpfungen: | → Zeitschrift |
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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers / Thatikonda, Venu [VerfasserIn]; 26 January 2023 (Online-Ressource)
