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Verfasst von:Hebach, Nils R. [VerfasserIn]   i
 Caro, Pilar [VerfasserIn]   i
 Martin-Giacalone, Bailey A. [VerfasserIn]   i
 Lupo, Philip J. [VerfasserIn]   i
 Marbach, Felix [VerfasserIn]   i
 Choukair, Daniela [VerfasserIn]   i
 Schaaf, Christian P. [VerfasserIn]   i
Titel:A retrospective analysis of growth hormone therapy in children with Schaaf-Yang syndrome
Verf.angabe:Nils R. Hebach, Pilar Caro, Bailey A. Martin-Giacalone, Philip J. Lupo, Felix Marbach, Daniela Choukair, Christian Patrick Schaaf
Jahr:2021
Umfang:10 S.
Fussnoten:Gesehen am 04.04.2023
Titel Quelle:Enthalten in: Clinical genetics
Ort Quelle:Oxford : Wiley-Blackwell, 1970
Jahr Quelle:2021
Band/Heft Quelle:100(2021), 3, Seite 298-307
ISSN Quelle:1399-0004
Abstract:Short stature is a common phenotype in children with Schaaf-Yang syndrome (SYS). Prader-Willi syndrome (PWS) and SYS share several phenotypic features including short stature, muscular hypotonia and developmental delay/intellectual disability. Evidence exists that similar to PWS, growth hormone (GH) deficiency may also be a feature of SYS. Recombinant human GH (rhGH) therapy has been approved for PWS, but the effects of rhGH therapy in individuals with SYS have not yet been documented. This retrospective, questionnaire-based study analyzes the prevalence of rhGH therapy in children with SYS, the effects of rhGH therapy on anthropometric measures, and parental perception of the treatment. Twenty-six individuals with SYS were sent a clinical questionnaire and a request for growth charts. We found a significant increase in height z-score (p* = 0.04) as well as a significant decrease in body mass index 6 months after rhGH therapy initiation (p* = 0.04). Furthermore, height z-scores of the treated group (mean z-score = −1.00) were significantly higher than those of the untreated group (mean z-score = −3.36, p = 0.01) at time of enrollment. All parents reported an increase in muscle strength and endurance, and several families noted beneficial effects such as improved cognition and motor development.
DOI:doi:10.1111/cge.14000
URL:kostenfrei: Volltext: https://doi.org/10.1111/cge.14000
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.14000
 DOI: https://doi.org/10.1111/cge.14000
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:clinical genetics
 neurodevelopmental disorder
 pediatric endocrinology
 rare disease
K10plus-PPN:1841220205
Verknüpfungen:→ Zeitschrift
 
 
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