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| Verfasst von: | Tauziède-Espariat, Arnault [VerfasserIn]  |
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| | Uro-Coste, Emmanuelle [VerfasserIn] |
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| | Sievers, Philipp [VerfasserIn] |
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| | Nicaise, Yvan [VerfasserIn] |
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| | Mariet, Cassandra [VerfasserIn] |
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| | Siegfried, Aurore [VerfasserIn] |
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| | Pierron, Gaëlle [VerfasserIn] |
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| | Guillemot, Delphine [VerfasserIn] |
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| | Benzakoun, Joseph [VerfasserIn] |
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| | Pallud, Johan [VerfasserIn] |
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| | Roques, Margaux [VerfasserIn] |
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| | Bonneville, Fabrice [VerfasserIn] |
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| | Larrieu-Ciron, Delphine [VerfasserIn] |
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| | Chaynes, Patrick [VerfasserIn] |
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| | Saffroy, Raphaël [VerfasserIn] |
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| | Hamelin, Jocelyne [VerfasserIn] |
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| | Hasty, Lauren [VerfasserIn] |
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| | Métais, Alice [VerfasserIn] |
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| | Chrétien, Fabrice [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Gojo, Johannes [VerfasserIn] |
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| | Varlet, Pascale [VerfasserIn] |
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| Titel: | CNS tumor with EP300 |
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| Titelzusatz: | :BCOR fusion: discussing its prevalence in adult population |
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| Verf.angabe: | Arnault Tauziède-Espariat, Emmanuelle Uro-Coste, Philipp Sievers, Yvan Nicaise, Cassandra Mariet, Aurore Siegfried, Gaëlle Pierron, Delphine Guillemot, Joseph Benzakoun, Johan Pallud, Margaux Roques, Fabrice Bonneville, Delphine Larrieu-Ciron, Patrick Chaynes, Raphaël Saffroy, Jocelyne Hamelin, Lauren Hasty, Alice Métais, Fabrice Chrétien, Marcel Kool, Johannes Gojo, Pascale Varlet on behalf of RENOCLIP-LOC |
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| E-Jahr: | 2023 |
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| Jahr: | 13 February 2023 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 05.04.2023 |
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| Titel Quelle: | Enthalten in: Acta Neuropathologica Communications |
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| Ort Quelle: | London : Biomed Central, 2013 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 11(2023) vom: Feb., Artikel-ID 26, Seite 1-7 |
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| ISSN Quelle: | 2051-5960 |
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| Abstract: | The Central Nervous System (CNS) tumor with BCOR internal tandem duplication (ITD) has recently been added as a novel embryonal histomolecular tumor type to the 2021 World Health Organization (WHO) Classification of CNS Tumors. In addition, other CNS tumors harboring a BCOR/BCORL1 fusion, which are defined by a distinct DNA-methylation profile, have been recently identified in the literature but clinical, radiological and histopathological data remain scarce. Herein, we present two adult cases of CNS tumors with EP300::BCOR fusion. These two cases presented radiological, histopathological, and immunohistochemical homologies with CNS tumors having BCOR ITD in children. To compare these tumors with different BCOR alterations, we performed a literature review with a meta-analysis. CNS tumors with EP300::BCOR fusion seem to be distinct from their BCOR ITD counterparts in terms of age, location, progression-free survival, tumor growth pattern, and immunopositivity for the BCOR protein. CNS tumors from the EP300::BCOR fusion methylation class in adults may be added to the future WHO classification. |
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| DOI: | doi:10.1186/s40478-023-01523-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1186/s40478-023-01523-y |
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| | DOI: https://doi.org/10.1186/s40478-023-01523-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | BCOR |
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| | EP300 |
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| K10plus-PPN: | 1841486442 |
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| Verknüpfungen: | → Zeitschrift |
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CNS tumor with EP300 / Tauziède-Espariat, Arnault [VerfasserIn]; 13 February 2023 (Online-Ressource)
