| Online-Ressource |
Verfasst von: | Heesch, Sandra Anja [VerfasserIn]  |
| Schlee, C. [VerfasserIn]  |
| Neumann, M. [VerfasserIn]  |
| Stroux, A. [VerfasserIn]  |
| Kühnl, A. [VerfasserIn]  |
| Schwartz, S. [VerfasserIn]  |
| Haferlach, T. [VerfasserIn]  |
| Goekbuget, N. [VerfasserIn]  |
| Hoelzer, D. [VerfasserIn]  |
| Thiel, E. [VerfasserIn]  |
| Hofmann, Wolf-Karsten [VerfasserIn]  |
| Baldus, C. D. [VerfasserIn]  |
Titel: | BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia |
Verf.angabe: | S. Heesch, C. Schlee, M. Neumann, A. Stroux, A. Kühnl, S. Schwartz, T. Haferlach, N. Goekbuget, D. Hoelzer, E. Thiel, W.-K. Hofmann, C. D. Baldus |
E-Jahr: | 2010 |
Jahr: | 10 June 2010 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 11.04.2023 |
Titel Quelle: | Enthalten in: Leukemia |
Ort Quelle: | London : Springer Nature, 1997 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 24(2010), 8, Seite 1429-1436 |
ISSN Quelle: | 1476-5551 |
Abstract: | Over expression of BAALC (brain and acute leukemia, cytoplasmic) predicts an inferior outcome in acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. To identify BAALC-associated genes that give insights into its functional role in chemotherapy resistance, gene expression signatures differentiating high from low BAALC expressers were generated from normal CD34+ progenitors, T-acute lymphoblastic leukemia (T-ALL) and AML samples. The insulin-like growth factor binding protein 7 (IGFBP7) was one of the four genes (CD34, CD133, natriuretic peptide receptor C (NPR3), IGFBP7) coexpressed with BAALC and common to the three entities. In T-ALL, high IGFBP7-expression was associated with an immature phenotype of early T-ALL (P<0.001), expression of CD34 (P<0.001) and CD33 (P<0.001). Moreover, high IGFBP7-expression predicted primary therapy resistance (P=0.03) and inferior survival in T-ALL (P=0.03). In vitro studies revealed that IGFBP7 protein significantly inhibited the proliferation of leukemia cell lines (Jurkat cells: 42% reduction, P=0.002; KG1a cells: 65% reduction, P<0.001). In conclusion, IGFBP7 was identified as a BAALC coexpressed gene. Furthermore, high IGFBP7 was associated with stem cell features and treatment failure in T-ALL. In contrast to BAALC, which likely represents only a surrogate marker of treatment failure in acute leukemia, IGFBP7 regulates the proliferation of leukemic cells and might be involved in chemotherapy resistance. |
DOI: | doi:10.1038/leu.2010.130 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/leu.2010.130 |
| Volltext: https://www.nature.com/articles/leu2010130 |
| DOI: https://doi.org/10.1038/leu.2010.130 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Acute lymphocytic leukaemia |
| Acute myeloid leukaemia |
| Cancer therapeutic resistance |
| Gene expression profiling |
K10plus-PPN: | 184195554X |
Verknüpfungen: | → Zeitschrift |
BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia / Heesch, Sandra Anja [VerfasserIn]; 10 June 2010 (Online-Ressource)