Repeated low-dose computed tomography in current and former smokers for quantification of emphysema

• Verfasst von: McGregor, Alexander [VerfasserIn]
• Verfasst von: Roberts, Heidi C. [VerfasserIn]
• Verfasst von: Dong, Zhi [VerfasserIn]
• Verfasst von: Menezes, Ravi [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Weinheimer, Oliver [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Titel: Repeated low-dose computed tomography in current and former smokers for quantification of emphysema
• Verf.angabe: Alexander McGregor, Heidi C. Roberts, MD, Zhi Dong, MD, Ravi Menezes, PhD, Hans-Ulrich Kauczor, MD, Oliver Weinheimer, MD, and Claus Peter Heussel, MD
• Jahr: 2010
• Umfang: 6 S.
• Fussnoten: Gesehen am 12.04.2023
• Titel Quelle: Enthalten in: Journal of computer assisted tomography
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1977
• Jahr Quelle: 2010
• Band/Heft Quelle: 34(2010), 6 vom: Nov./Dez., Seite 933-938
• ISSN Quelle: 1532-3145
• DOI: doi:10.1097/RCT.0b013e3181ef9fbe
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1842058622

Abstract

Objective: - To quantify different emphysema evolution in current and former smokers. - Methods: - We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile. - Results: - The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = −0.257%, P = 0.004; and ΔEVcurrent = −0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers. - Conclusions: - We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers.