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| Verfasst von: | Caydasi, Ayse Koca [VerfasserIn]  |
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| | Khmelinskii, Anton [VerfasserIn] |
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| | Darieva, Zoulfia [VerfasserIn] |
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| | Kurtulmus, Bahtiyar [VerfasserIn] |
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| | Knop, Michael [VerfasserIn] |
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| | Pereira, Gislene [VerfasserIn] |
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| Titel: | SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest |
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| Verf.angabe: | Ayse Koca Caydasi, Anton Khmelinskii, Zoulfia Darieva, Bahtiyar Kurtulmus, Michael Knop, and Gislene Pereira |
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| E-Jahr: | 2023 |
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| Jahr: | 13 Jan 2023 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 14.04.2023 |
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| Titel Quelle: | Enthalten in: Molecular biology of the cell |
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| Ort Quelle: | Bethesda, Md. : American Society for Cell Biology, 1992 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 34(2023), 2, Artikel-ID ar11, Seite 1-15 |
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| ISSN Quelle: | 1939-4586 |
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| Abstract: | Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to daughter cell polarity axis. When the anaphase spindle is not correctly positioned, a surveillance mechanism, named as the spindle position checkpoint (SPOC), prevents the progression out of mitosis until correct spindle positioning is achieved. How SPOC works on a molecular level is not well understood. Here we performed a genome-wide genetic screen to search for components required for SPOC. We identified the SWR1 chromatin-remodeling complex (SWR1-C) among several novel factors that are essential for SPOC integrity. Cells lacking SWR1-C were able to activate SPOC upon spindle misorientation but underwent mitotic slippage upon prolonged SPOC arrest. This mitotic slippage required the Cdc14-early anaphase release pathway and other factors including the SAGA (Spt-Ada-Gcn5 acetyltransferase) histone acetyltransferase complex, proteasome components and the mitotic cyclin-dependent kinase inhibitor Sic1. Together, our data establish a novel link between SWR1-C chromatin remodeling and robust checkpoint arrest in late anaphase. |
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| DOI: | doi:10.1091/mbc.E20-03-0179 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1091/mbc.E20-03-0179 |
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| | Volltext: https://www.molbiolcell.org/doi/10.1091/mbc.E20-03-0179 |
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| | DOI: https://doi.org/10.1091/mbc.E20-03-0179 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1842684671 |
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| Verknüpfungen: | → Zeitschrift |
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SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest / Caydasi, Ayse Koca [VerfasserIn]; 13 Jan 2023 (Online-Ressource)
