Re "Underlying genetic models of inheritance in established type 2 diabetes associations"

• Verfasst von: Hemminki, Kari [VerfasserIn]
• Verfasst von: Försti, Asta [VerfasserIn]
• Verfasst von: Lorenzo Bermejo, Justo [VerfasserIn]
• Titel: Re "Underlying genetic models of inheritance in established type 2 diabetes associations"
• Verf.angabe: Kari Hemminki, Asta Försti, and Justo Lorenzo Bermejo
• E-Jahr: 2010
• Jahr: 13 April 2010
• Umfang: 2 S.
• Fussnoten: Gesehen am 19.04.2023
• Titel Quelle: Enthalten in: American journal of epidemiology
• Ort Quelle: Oxford : Oxford Univ. Press, 1921
• Jahr Quelle: 2010
• Band/Heft Quelle: 171(2010), 10 vom: Apr., Seite 1153-1154
• ISSN Quelle: 1476-6256
• DOI: doi:10.1093/aje/kwq058
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Kommentar zu: Salanti, G.: Underlying genetic models of inheritance in established type 2 diabetes associations, in: American Journal of Epidemiology
• K10plus-PPN: 1843126400

Abstract

Genome-wide association studies have identified a large number of disease susceptibility loci of unknown function, characterized by high allele frequencies and low relative risks. This is also the case for type 2 diabetes for which Salanti et al. (1) identified 17 replicated associations from 19 studies. The odds ratios (ORs) for risk homozygotes ranged from 1.10 to 1.61. The authors compared genetic models for genotype effects and found that for 13 loci the data fitted best to the additive model, while for the remaining loci the discrimination between the additive and other models was not clear. The authors concluded that their results may be useful for predictive modeling and for designing biologic and functional experiments.