| |  Online-Ressource |
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| Verfasst von: | Lubjuhn, Judith [VerfasserIn]  |
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| | Gastens, Alexandra [VerfasserIn] |
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| | von Wilpert, Gertrud [VerfasserIn] |
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| | Bargiotas, Panagiotis [VerfasserIn] |
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| | Herrmann, Oliver [VerfasserIn] |
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| | Murikinati, Sasidhar [VerfasserIn] |
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| | Rabie, Tamer [VerfasserIn] |
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| | Marti, Hugo [VerfasserIn] |
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| | Amende, Ivo [VerfasserIn] |
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| | Hampton, Tom G. [VerfasserIn] |
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| | Schwaninger, Markus [VerfasserIn] |
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| Titel: | Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery |
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| Verf.angabe: | Judith Lubjuhn, Alexandra Gastens, Gertrud von Wilpert, Panagiotis Bargiotas, Oliver Herrmann, Sasidhar Murikinati, Tamer Rabie, Hugo Marti, Ivo Amende, Tom G. Hampton, Markus Schwaninger |
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| E-Jahr: | 2009 |
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| Jahr: | 4 August 2009 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 19.04.2023 |
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| Titel Quelle: | Enthalten in: Journal of neuroscience methods |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 184(2009), 1 vom: Okt., Seite 95-103 |
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| ISSN Quelle: | 1872-678X |
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| Abstract: | Reducing post-stroke disability is the major goal of stroke therapy. Consequently, functional testing is essential in experimental stroke studies to increase the predictive value of animal models. We used several sensory and motor tests to assess functional disability in a mouse model of permanent distal middle cerebral artery occlusion (pdMCAO) that induced mainly cortical infarcts. Gait dynamics were transiently disturbed after pdMCAO as measured by different analysis techniques. Stance and brake duration were shorter after pdMCAO. Consistent with sensory and motor deficits the latency to move was prolonged up to 14 days after pdMCAO and the performance in the corner test and handedness were affected on day 1 or 2 after pdMCAO. Heart rate was decreased and heart rate variability were increased after pdMCAO indicating sympathetic-parasympathetic imbalance. In summary, pdMCAO-induced cortical infarcts lead to clinically relevant sensory, motor and cardiac autonomic dysfunction in mice. The present study provides a basis to explore the potential of functional testing for neuroprotection and neuroregeneration after stroke. |
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| DOI: | doi:10.1016/j.jneumeth.2009.07.029 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jneumeth.2009.07.029 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0165027009004294 |
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| | DOI: https://doi.org/10.1016/j.jneumeth.2009.07.029 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Errata: Lubjuhn, Judith: Corrigendum to “Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery” [J. Neurosci. Methods 184 (2009) 95-103] |
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| Sach-SW: | Functional testing |
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| | Gait |
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| | Heart rate variability |
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| | Locomotor activity |
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| | Stroke |
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| K10plus-PPN: | 1843126451 |
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| Verknüpfungen: | → Zeitschrift |
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Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery / Lubjuhn, Judith [VerfasserIn]; 4 August 2009 (Online-Ressource)
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