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Status: Bibliographieeintrag

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Verfasst von:Chrysostomou, Eleni [VerfasserIn]   i
 Flici, Hakima [VerfasserIn]   i
 Gornik, Sebastian G. [VerfasserIn]   i
 Salinas-Saavedra, Miguel [VerfasserIn]   i
 Gahan, James M [VerfasserIn]   i
 McMahon, Emma T [VerfasserIn]   i
 Thompson, Kerry [VerfasserIn]   i
 Hanley, Shirley [VerfasserIn]   i
 Kilcoyne, Michelle [VerfasserIn]   i
 Schnitzler, Christine E [VerfasserIn]   i
 Gonzalez, Paul [VerfasserIn]   i
 Baxevanis, Andreas D [VerfasserIn]   i
 Frank, Uri [VerfasserIn]   i
Titel:A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
Verf.angabe:Eleni Chrysostomou, Hakima Flici, Sebastian G Gornik, Miguel Salinas-Saavedra, James M Gahan, Emma T McMahon, Kerry Thompson, Shirley Hanley, Michelle Kilcoyne, Christine E Schnitzler, Paul Gonzalez, Andreas D Baxevanis, Uri Frank
E-Jahr:2022
Jahr:June 7, 2022
Umfang:24 S.
Fussnoten:Gesehen am 19.04.2023
Titel Quelle:Enthalten in: eLife
Ort Quelle:Cambridge : eLife Sciences Publications, 2012
Jahr Quelle:2022
Band/Heft Quelle:11(2022), Artikel-ID e78793, Seite 1-24
ISSN Quelle:2050-084X
Abstract:Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their neural function evolved is unclear. Here, we use Hydractinia symbiolongicarpus, a member of the early-branching phylum Cnidaria, to provide insight into this question. Using a combination of mRNA in situ hybridization, transgenesis, gene knockdown, transcriptomics, and in vivo imaging, we provide a comprehensive molecular and cellular analysis of neurogenesis during embryogenesis, homeostasis, and regeneration in this animal. We show that SoxB genes act sequentially at least in some cases. Stem cells expressing Piwi1 and Soxb1, which have broad developmental potential, become neural progenitors that express Soxb2 before differentiating into mature neural cells. Knockdown of SoxB genes resulted in complex defects in embryonic neurogenesis. Hydractinia neural cells differentiate while migrating from the aboral to the oral end of the animal, but it is unclear whether migration per se or exposure to different microenvironments is the main driver of their fate determination. Our data constitute a rich resource for studies aiming at addressing this question, which is at the heart of understanding the origin and development of animal nervous systems.
DOI:doi:10.7554/eLife.78793
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.7554/eLife.78793
 DOI: https://doi.org/10.7554/eLife.78793
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cnidaria
 development
 evolution
 Hydractinia
 neurogenesis
 regeneration
 stem cells
K10plus-PPN:1843129353
Verknüpfungen:→ Zeitschrift

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