Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells

• Verfasst von: Shenegelegn Mern, Demissew [VerfasserIn]
• Verfasst von: Hasskarl, Jens [VerfasserIn]
• Verfasst von: Burwinkel, Barbara [VerfasserIn]
• Titel: Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells
• Verf.angabe: DS Mern, J Hasskarl and B Burwinkel
• E-Jahr: 2010
• Jahr: 14 September 2010
• Umfang: 8 S.
• Fussnoten: Gesehen am 19.04.2023
• Titel Quelle: Enthalten in: British journal of cancer
• Ort Quelle: Edinburgh : Nature Publ. Group, 1999
• Jahr Quelle: 2010
• Band/Heft Quelle: 103(2010), 8, Seite 1237-1244
• ISSN Quelle: 1532-1827
• DOI: doi:10.1038/sj.bjc.6605897
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apoptosis
• Sach-SW: Gene expression
• Sach-SW: Ovarian cancer
• K10plus-PPN: 1843168464

Abstract

Inhibitors of DNA-binding proteins (Id1-4), lacking the basic DNA-binding domain, function as dominant inhibitors of cell-cycle regulators. Overexpression of Id proteins promotes cancer cell proliferation and resistance against apoptosis. Level of Id protein expression, especially of Id1, correlates with poor differentiation, enhanced malignant potential and more aggressive clinical behaviour of ovarian tumours. Although overexpression of Ids has been found and shown to correlate with poor clinical outcome, their inhibition at protein level has never been studied.