Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Michallet, Mauricette [VerfasserIn]   i
 Sobh, M. [VerfasserIn]   i
 Milligan, D. [VerfasserIn]   i
 Morisset, S. [VerfasserIn]   i
 Niederwieser, D. [VerfasserIn]   i
 Koza, V. [VerfasserIn]   i
 Ruutu, T. [VerfasserIn]   i
 Russell, N. H. [VerfasserIn]   i
 Verdonck, L. [VerfasserIn]   i
 Dhedin, N. [VerfasserIn]   i
 Vitek, A. [VerfasserIn]   i
 Boogaerts, M. [VerfasserIn]   i
 Vindelov, L. [VerfasserIn]   i
 Finke, J. [VerfasserIn]   i
 Dubois, V. [VerfasserIn]   i
 Biezen, A. van [VerfasserIn]   i
 Brand, R. [VerfasserIn]   i
 Witte, T. de [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL
Titelzusatz:a retrospective study from the EBMT registry
Verf.angabe:M Michallet, M Sobh, D Milligan, S Morisset, D Niederwieser, V Koza, T Ruutu , NH Russell, L Verdonck, N Dhedin, A Vitek, M Boogaerts, L Vindelov, J Finke, V Dubois, A van Biezen, R Brand, T de Witte and P Dreger on behalf of the Chronic Leukemia Working Party of the EBMT
E-Jahr:2010
Jahr:12 August 2010
Umfang:7 S.
Fussnoten:Gesehen am 21.04.2023
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2010
Band/Heft Quelle:24(2010), 10, Seite 1725-1731
ISSN Quelle:1476-5551
Abstract:We analyzed 368 chronic lymphocytic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation reported to the EBMT registry between 1995 and 2007. There were 198 human leukocyte antigen (HLA)-identical siblings; among unrelated transplants, 31 were well matched in high resolution (‘well matched’ unrelated donor, WMUD), and 139 were mismatched (MM), including 30 matched in low resolution; 266 patients (72%) received reduced-intensity conditioning and 102 (28%) received standard. According to the EBMT risk score, 11% were in scores 1-3, 23% in score 4, 40% in score 5, 22% in score 6 and 4% in score 7. There was no difference in overall survival (OS) at 5 years between HLA-identical siblings (55% (48-64)) and WMUD (59% (41-84)), P=0.82. In contrast, OS was significantly worse for MM (37% (29-48) P=0.005) due to a significant excess of transplant-related mortality. Also OS worsened significantly when EBMT risk score increased. HLA matching had no significant impact on relapse (siblings: 24% (21-27); WMUD: 35% (26-44), P=0.11 and MM: 21% (18-24), P=0.81); alemtuzumab T-cell depletion and stem cell source (peripheral blood) were associated with an increased risk. Our findings support the use of WMUD as equivalent alternative to HLA-matched sibling donors for allogeneic HSCT in CLL, and justify the application of EBMT risk score in this disease.
DOI:doi:10.1038/leu.2010.165
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/leu.2010.165
 Volltext: https://www.nature.com/articles/leu2010165
 DOI: https://doi.org/10.1038/leu.2010.165
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell transplantation
 Chronic lymphocytic leukaemia
 Immunological techniques
 Prognosis
K10plus-PPN:1843352605
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69067825   QR-Code
zum Seitenanfang