| Online-Ressource |
Verfasst von: | Michallet, Mauricette [VerfasserIn]  |
| Sobh, M. [VerfasserIn]  |
| Milligan, D. [VerfasserIn]  |
| Morisset, S. [VerfasserIn]  |
| Niederwieser, D. [VerfasserIn]  |
| Koza, V. [VerfasserIn]  |
| Ruutu, T. [VerfasserIn]  |
| Russell, N. H. [VerfasserIn]  |
| Verdonck, L. [VerfasserIn]  |
| Dhedin, N. [VerfasserIn]  |
| Vitek, A. [VerfasserIn]  |
| Boogaerts, M. [VerfasserIn]  |
| Vindelov, L. [VerfasserIn]  |
| Finke, J. [VerfasserIn]  |
| Dubois, V. [VerfasserIn]  |
| Biezen, A. van [VerfasserIn]  |
| Brand, R. [VerfasserIn]  |
| Witte, T. de [VerfasserIn]  |
| Dreger, Peter [VerfasserIn]  |
Titel: | The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL |
Titelzusatz: | a retrospective study from the EBMT registry |
Verf.angabe: | M Michallet, M Sobh, D Milligan, S Morisset, D Niederwieser, V Koza, T Ruutu , NH Russell, L Verdonck, N Dhedin, A Vitek, M Boogaerts, L Vindelov, J Finke, V Dubois, A van Biezen, R Brand, T de Witte and P Dreger on behalf of the Chronic Leukemia Working Party of the EBMT |
E-Jahr: | 2010 |
Jahr: | 12 August 2010 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 21.04.2023 |
Titel Quelle: | Enthalten in: Leukemia |
Ort Quelle: | London : Springer Nature, 1997 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 24(2010), 10, Seite 1725-1731 |
ISSN Quelle: | 1476-5551 |
Abstract: | We analyzed 368 chronic lymphocytic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation reported to the EBMT registry between 1995 and 2007. There were 198 human leukocyte antigen (HLA)-identical siblings; among unrelated transplants, 31 were well matched in high resolution (‘well matched’ unrelated donor, WMUD), and 139 were mismatched (MM), including 30 matched in low resolution; 266 patients (72%) received reduced-intensity conditioning and 102 (28%) received standard. According to the EBMT risk score, 11% were in scores 1-3, 23% in score 4, 40% in score 5, 22% in score 6 and 4% in score 7. There was no difference in overall survival (OS) at 5 years between HLA-identical siblings (55% (48-64)) and WMUD (59% (41-84)), P=0.82. In contrast, OS was significantly worse for MM (37% (29-48) P=0.005) due to a significant excess of transplant-related mortality. Also OS worsened significantly when EBMT risk score increased. HLA matching had no significant impact on relapse (siblings: 24% (21-27); WMUD: 35% (26-44), P=0.11 and MM: 21% (18-24), P=0.81); alemtuzumab T-cell depletion and stem cell source (peripheral blood) were associated with an increased risk. Our findings support the use of WMUD as equivalent alternative to HLA-matched sibling donors for allogeneic HSCT in CLL, and justify the application of EBMT risk score in this disease. |
DOI: | doi:10.1038/leu.2010.165 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/leu.2010.165 |
| Volltext: https://www.nature.com/articles/leu2010165 |
| DOI: https://doi.org/10.1038/leu.2010.165 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Cell transplantation |
| Chronic lymphocytic leukaemia |
| Immunological techniques |
| Prognosis |
K10plus-PPN: | 1843352605 |
Verknüpfungen: | → Zeitschrift |
¬The¬ impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL / Michallet, Mauricette [VerfasserIn]; 12 August 2010 (Online-Ressource)