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Verfasst von:Horstmann, Solveig [VerfasserIn]   i
 Budig, Leila [VerfasserIn]   i
 Gardner, Humphrey [VerfasserIn]   i
 Koziol, James [VerfasserIn]   i
 Deuschle, Michael [VerfasserIn]   i
 Schilling, Claudia [VerfasserIn]   i
 Wagner, Simone [VerfasserIn]   i
Titel:Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease
Verf.angabe:Solveig Horstmann, Leila Budig, Humphrey Gardner, James Koziol, Michael Deuschle, Claudia Schilling and Simone Wagner
E-Jahr:2010
Jahr:18 June 2010
Umfang:7 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 21.04.2023
Titel Quelle:Enthalten in: International psychogeriatrics
Ort Quelle:Cambridge : Cambridge Univ. Press, 1989
Jahr Quelle:2010
Band/Heft Quelle:22(2010), 6, Seite 966-972
ISSN Quelle:1741-203X
Abstract:Background: Deposition of amyloid β in senile plaques and in cerebral blood vessels is one hallmark of the pathogenesis of Alzheimer's disease (AD). The ability of several matrix metalloproteinases (MMPs) to degrade amyloid precursor protein leading to aggregation of amyloid β, as well as the increased expression of MMPs in post mortem brain tissue of Alzheimer's patients, indicate that MMPs play an important role in the pathogenesis of AD.Methods: We investigated levels of MMP-2,-3,-9 and -10 in plasma and cerebrospinal fluid (CSF) of AD patients (n = 14) by gelatin and casein zymography. Comparisons between AD patients and controls relative to levels of MMP-2, MMP-3, MMP-9, and MMP-10 were made with Wilcoxon rank statistics. Pearson correlations were computed as measures of association.Results: MMP-3 in AD was significantly elevated in plasma (p = 0.006) and there was a trend towards increase in CSF (p = 0.05). MMP-2 in CSF of AD patients was significantly decreased (p = 0.02) while levels in plasma remained unchanged. MMP-9 and MMP-10 could not be detected in CSF; MMP-10 was unchanged in plasma, but MMP-9 was significantly decreased (p = 0.02).Conclusions: These findings constitute further evidence for the important role of MMPs in the pathogenesis of AD.
DOI:doi:10.1017/S1041610210000827
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1017/S1041610210000827
 Volltext: https://www.cambridge.org/core/journals/international-psychogeriatrics/article/matrix-metalloproteinases-in-peripheral-b ...
 DOI: https://doi.org/10.1017/S1041610210000827
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alzheimer's disease
 dementia
 matrix metalloproteinases
K10plus-PPN:1843359359
Verknüpfungen:→ Zeitschrift

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