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| Verfasst von: | Fichtner, Alexander [VerfasserIn]  |
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| | Süsal, Caner [VerfasserIn] |
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| | Höcker, Britta [VerfasserIn] |
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| | Rieger, Susanne [VerfasserIn] |
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| | Waldherr, Rüdiger [VerfasserIn] |
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| | Westhoff, Jens [VerfasserIn] |
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| | Sander, Anja [VerfasserIn] |
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| | Dragun, Duska [VerfasserIn] |
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| | Tönshoff, Burkhard [VerfasserIn] |
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| Titel: | Association of non-HLA antibodies against endothelial targets and donor-specific HLA antibodies with antibody-mediated rejection and graft function in pediatric kidney transplant recipients |
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| Verf.angabe: | Alexander Fichtner, Caner Süsal, Britta Höcker, Susanne Rieger, Rüdiger Waldherr, Jens H.Westhoff, Anja Sander, Duska Dragun, Burkhard Tönshoff |
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| E-Jahr: | 2021 |
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| Jahr: | 24 March 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Korrigierte Veröffentlichung 2021 ; Gesehen am 24.04.2023 |
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| Titel Quelle: | Enthalten in: Pediatric nephrology |
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| Ort Quelle: | Berlin : Springer, 1987 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 36(2021), 8, Seite 2473-2484 |
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| ISSN Quelle: | 1432-198X |
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| Abstract: | Background Non-HLA antibodies against endothelial targets have been implicated in the pathogenesis of antibody-mediated rejection (ABMR), but data in pediatric patients are scarce. - Methods We retrospectively analyzed a carefully phenotyped single-center (University Children’s Hospital Heidelberg, Germany) cohort of 62 pediatric kidney transplant recipients (mean age at transplantation, 8.6 ± 5.0 years) at increased risk of graft function deterioration. Patients had received their transplant between January 1, 1999, and January 31, 2010. We examined at time of late index biopsies (more than 1-year post-transplant, occurring after January 2004) the association of antibodies against the angiotensin II type 1 receptor (AT1R), the endothelin type A receptor (ETAR), the MHC class I chain-like gene A (MICA), and vimentin in conjunction with overall and complement-binding donor-specific HLA antibodies (HLA-DSA) with graft histology and function. - Results We observed a high prevalence (62.9%) of non-HLA antibody positivity. Seventy-two percent of HLA-DSA positive patients showed additional positivity for at least one non-HLA antibody. Antibodies against AT1R, ETAR, and MICA were associated with the histological phenotype of ABMR. The cumulative load of HLA-DSA and non-HLA antibodies in circulation was related to the degree of microinflammation in peritubular capillaries. Non-HLA antibody positivity was an independent noninvasive risk factor for graft function deterioration (adjusted hazard ratio 6.38, 95% CI, 2.11-19.3). - Conclusions Our data indicate that the combined detection of antibodies to HLA and non-HLA targets may allow a more comprehensive assessment of the patients’ immune responses against the kidney allograft and facilitates immunological risk stratification. |
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| DOI: | doi:10.1007/s00467-021-04969-1 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1007/s00467-021-04969-1 |
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| | kostenfrei: Volltext: https://link.springer.com/10.1007/s00467-021-04969-1 |
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| | DOI: https://doi.org/10.1007/s00467-021-04969-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1843428652 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Association of non-HLA antibodies against endothelial targets and donor-specific HLA antibodies with antibody-mediated rejection and graft function in pediatric kidney transplant recipients / Fichtner, Alexander [VerfasserIn]; 24 March 2021 (Online-Ressource)
