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| Verfasst von: | Lin, Yanting [VerfasserIn]  |
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| | Cui, Xinmeng [VerfasserIn] |
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| | Cao, Qiuhua [VerfasserIn] |
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| | Bi, Ran [VerfasserIn] |
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| | Liu, Yiming [VerfasserIn] |
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| | Jing, Dongquan [VerfasserIn] |
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| | Yue, Chongxiu [VerfasserIn] |
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| | Zhao, Qixiang [VerfasserIn] |
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| | Wang, Yue [VerfasserIn] |
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| | Liu, Siliang [VerfasserIn] |
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| | Su, Yali [VerfasserIn] |
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| | Formoso, Karina [VerfasserIn] |
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| | Susperreguy, Sebastian [VerfasserIn] |
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| | Birnbaumer, Lutz [VerfasserIn] |
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| | Freichel, Marc [VerfasserIn] |
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| | Yang, Yong [VerfasserIn] |
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| | You, Linjun [VerfasserIn] |
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| | Gao, Xinghua [VerfasserIn] |
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| Titel: | TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis |
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| Verf.angabe: | Yanting Lin, Xinmeng Cui, Qiuhua Cao, Ran Bi, Yiming Liu, Dongquan Jing, Chongxiu Yue, Qixiang Zhao, Yue Wang, Siliang Liu, Yali Su, Karina Formoso, Sebastian Susperreguy, Lutz Birnbaumer, Marc Freichel, Yong Yang, Linjun You, Xinghua Gao |
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| E-Jahr: | 2023 |
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| Jahr: | February 2023 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht am 31. Dezember 2022 ; Gesehen am 30.11.2023 |
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| Titel Quelle: | Enthalten in: International immunopharmacology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2001 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 115(2023) vom: Feb., Artikel-ID 109655, Seite 1-13 |
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| ISSN Quelle: | 1878-1705 |
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| Abstract: | The transient receptor potential canonical (TRPC) channels, encoded in seven non-allelic genes, are important contributors to calcium fluxes, are strongly associated with various diseases. Here we explored the consequences of ablating all seven TRPCs in mice focusing on colitis. We discovered that absence of all seven TRPC proteins in mice (TRPC HeptaKO mice) promotes the development of dextran sulfate sodium (DSS)-induced colitis. RNA-sequence analysis highlighted an extremely pro-inflammatory profile in colons of DSS-treated TRPC HeptaKO mice, with an amount of increased pro-inflammatory cytokines and chemokines. Flow cytometry analysis showed that the infiltration of Ly6Chi monocytes and neutrophils in colonic lamina propria was significantly increased in DSS-treated TRPC HeptaKO mice. Results also revealed that macrophages from TRPC HeptaKO mice exhibited M1 polarization and enhanced secretion of pro-inflammatory factors. In addition, the composition of gut microbiota was markedly disturbed in DSS-treated TRPC HeptaKO mice. However, upon antibiotic cocktail (Abx)-treatment, TRPC HeptaKO mice showed no significant differences with WT mice in disease severity. Collectively, these data suggest that ablation of all TRPCs promotes the development of DSS-induced colitis by inducing pro-inflammatory macrophages and gut microbiota disorder. |
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| DOI: | doi:10.1016/j.intimp.2022.109655 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.intimp.2022.109655 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1567576922011407 |
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| | DOI: https://doi.org/10.1016/j.intimp.2022.109655 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Abx-treatment |
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| | DSS-induced colitis |
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| | Gut microbiota |
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| | Macrophages |
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| | TRPC HeptaKO |
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| K10plus-PPN: | 1843479249 |
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| Verknüpfungen: | → Zeitschrift |
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TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis / Lin, Yanting [VerfasserIn]; February 2023 (Online-Ressource)
