Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions

• Verfasst von: Madan Renes, Vanesa [VerfasserIn]
• Verfasst von: Redondo Rodríguez, Natalia [VerfasserIn]
• Verfasst von: Carrasco, Luis [VerfasserIn]
• Titel: Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions
• Verf.angabe: Vanesa Madan, Natalia Redondo and Luis Carrasco
• E-Jahr: 2010
• Jahr: 22 April 2010
• Umfang: 14 S.
• Fussnoten: Gesehen am 25.04.2023
• Titel Quelle: Enthalten in: Cellular microbiology
• Ort Quelle: London : Hindawi Limited, 1999
• Jahr Quelle: 2010
• Band/Heft Quelle: 12(2010), 8 vom: Aug., Seite 1144-1157
• ISSN Quelle: 1462-5822
• DOI: doi:10.1111/j.1462-5822.2010.01460.x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 184349549X

Abstract

Poliovirus 2B protein is a well-known viroporin implicated in plasma membrane permeabilization to ions and low-molecular-weight compounds during infection. Translation in mammalian cells expressing 2B protein is inhibited by hygromycin B (HB) but remains unaffected in mock cells, which are not permeable to the inhibitor. Here we describe a previously unreported bystander effect in which healthy baby hamster kidney (BHK) cells become sensitive to HB when co-cultured with a low proportion of cells expressing poliovirus 2B.