Interpreting iron homeostasis in congenital and acquired disorders

• Verfasst von: Scaramellini, Natalia [VerfasserIn]
• Verfasst von: Fischer, Dania [VerfasserIn]
• Verfasst von: Agarvas, Anand R. [VerfasserIn]
• Verfasst von: Motta, Irene [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Verfasst von: Mertens, Christina [VerfasserIn]
• Titel: Interpreting iron homeostasis in congenital and acquired disorders
• Verf.angabe: Natalia Scaramellini, Dania Fischer, Anand R. Agarvas, Irene Motta, Martina U. Muckenthaler and Christina Mertens
• E-Jahr: 2023
• Jahr: 21 February 2023
• Umfang: 19 S.
• Fussnoten: Gesehen am 25.04.2023
• Titel Quelle: Enthalten in: Pharmaceuticals
• Ort Quelle: Basel : MDPI, 2004
• Jahr Quelle: 2023
• Band/Heft Quelle: 16(2023), 3 vom: Feb., Artikel-ID 329, Seite 1-19
• ISSN Quelle: 1424-8247
• DOI: doi:10.3390/ph16030329
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: anemia
• Sach-SW: hematology
• Sach-SW: hemochromatosis
• Sach-SW: iron
• Sach-SW: iron deficiency
• Sach-SW: iron metabolism
• Sach-SW: iron overload
• Sach-SW: rare disease
• K10plus-PPN: 1843496178

Abstract

Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future.