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| Verfasst von: | Gkeka, Anastasia [VerfasserIn]  |
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| | Aresta-Branco, Francisco [VerfasserIn] |
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| | Triller, Gianna [VerfasserIn] |
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| | Vlachou, Evi P. [VerfasserIn] |
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| | Straaten, Monique van [VerfasserIn] |
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| | Lilic, Mirjana [VerfasserIn] |
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| | Olinares, Paul Dominic B. [VerfasserIn] |
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| | Perez, Kathryn [VerfasserIn] |
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| | Chait, Brian T. [VerfasserIn] |
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| | Blatnik, Renata [VerfasserIn] |
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| | Ruppert, Thomas [VerfasserIn] |
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| | Verdi, Joseph P. [VerfasserIn] |
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| | Stebbins, Erec [VerfasserIn] |
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| | Papavasiliou, Nina [VerfasserIn] |
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| Titel: | Immunodominant surface epitopes power immune evasion in the African trypanosome |
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| Verf.angabe: | Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou |
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| E-Jahr: | 2023 |
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| Jahr: | 20 March 2023 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 25.04.2023 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 42(2023), 3 vom: März, Artikel-ID 112262, Seite 1-21 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. We show that the repertoires are highly restricted and are directed predominantly to distinct epitopes on the surface of the VSGs. They are also highly discriminatory; minor alterations within these exposed epitopes confer antigenically distinct properties to these VSGs and elicit different repertoires. We propose that the patterned and repetitive nature of the VSG coat focuses host immunity to a restricted set of immunodominant epitopes per VSG, eliciting a highly stereotyped response, minimizing cross-reactivity between different VSGs and facilitating prolonged immune evasion through epitope variation. |
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| DOI: | doi:10.1016/j.celrep.2023.112262 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2023.112262 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723002735 |
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| | DOI: https://doi.org/10.1016/j.celrep.2023.112262 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | African trypanosome |
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| | antibody repertoires |
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| | antigenic variation |
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| | host-pathogen interactions |
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| | immune evasion |
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| | immunodominance |
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| | immunogenic epitopes |
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| | post-translational modification |
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| | variant surface glycoproteins |
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| K10plus-PPN: | 1843497948 |
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| Verknüpfungen: | → Zeitschrift |
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Immunodominant surface epitopes power immune evasion in the African trypanosome / Gkeka, Anastasia [VerfasserIn]; 20 March 2023 (Online-Ressource)
