| |  Online-Ressource |
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| Verfasst von: | Falkner, Florian [VerfasserIn]  |
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| | Mayer, Simon Andreas [VerfasserIn] |
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| | Thomas, Benjamin [VerfasserIn] |
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| | Zimmermann, Sarah Onon [VerfasserIn] |
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| | Walter, Sonja [VerfasserIn] |
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| | Heimel, Patrick [VerfasserIn] |
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| | Thiele, Wilko [VerfasserIn] |
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| | Sleeman, Jonathan P. [VerfasserIn] |
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| | Bigdeli, Amir Khosrow [VerfasserIn] |
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| | Kiss, Herbert [VerfasserIn] |
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| | Podesser, Bruno Karl [VerfasserIn] |
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| | Kneser, Ulrich [VerfasserIn] |
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| | Bergmeister, Helga [VerfasserIn] |
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| | Schneider, Karl Heinrich [VerfasserIn] |
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| Titel: | Acellular human placenta small-diameter vessels as a favorable source of super-microsurgical vascular replacements |
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| Titelzusatz: | a proof of concept |
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| Verf.angabe: | Florian Falkner, Simon Andreas Mayer, Benjamin Thomas, Sarah Onon Zimmermann, Sonja Walter, Patrick Heimel, Wilko Thiele, Jonathan Paul Sleeman, Amir Khosrow Bigdeli, Herbert Kiss, Bruno Karl Podesser, Ulrich Kneser, Helga Bergmeister and Karl Heinrich Schneider |
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| E-Jahr: | 2023 |
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| Jahr: | 7 March 2023 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 25.04.2023 |
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| Titel Quelle: | Enthalten in: Bioengineering |
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| Ort Quelle: | Basel : MDPI, 2014 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 10(2023), 3, Artikel-ID 337, Seite 1-13 |
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| ISSN Quelle: | 2306-5354 |
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| Abstract: | In this study, we aimed to evaluate the human placenta as a source of blood vessels that can be harvested for vascular graft fabrication in the submillimeter range. Our approach included graft modification to prevent thrombotic events. Submillimeter arterial grafts harvested from the human placenta were decellularized and chemically crosslinked to heparin. Graft performance was evaluated using a microsurgical arteriovenous loop (AVL) model in Lewis rats. Specimens were evaluated through hematoxylin-eosin and CD31 staining of histological sections to analyze host cell immigration and vascular remodeling. Graft patency was determined 3 weeks after implantation using a vascular patency test, histology, and micro-computed tomography. A total of 14 human placenta submillimeter vessel grafts were successfully decellularized and implanted into AVLs in rats. An appropriate inner diameter to graft length ratio of 0.81 ± 0.16 mm to 7.72 ± 3.20 mm was achieved in all animals. Grafts were left in situ for a mean of 24 ± 4 days. Decellularized human placental grafts had an overall patency rate of 71% and elicited no apparent immunological responses. Histological staining revealed host cell immigration into the graft and re-endothelialization of the vessel luminal surface. This study demonstrates that decellularized vascular grafts from the human placenta have the potential to serve as super-microsurgical vascular replacements. |
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| DOI: | doi:10.3390/bioengineering10030337 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/bioengineering10030337 |
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| | Volltext: https://www.mdpi.com/2306-5354/10/3/337 |
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| | DOI: https://doi.org/10.3390/bioengineering10030337 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | arteriovenous loop |
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| | human placenta |
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| | small diameter vascular grafts |
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| | super-microsurgery |
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| K10plus-PPN: | 1843504065 |
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| Verknüpfungen: | → Zeitschrift |
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Acellular human placenta small-diameter vessels as a favorable source of super-microsurgical vascular replacements / Falkner, Florian [VerfasserIn]; 7 March 2023 (Online-Ressource)
