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| Verfasst von: | Zhang, Jing-Jing [VerfasserIn]  |
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| | Xu, Qi-Jie [VerfasserIn] |
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| | Schmidt, Claudia [VerfasserIn] |
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| | Abu El Maaty, Mohamed A. [VerfasserIn] |
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| | Song, Jinglin [VerfasserIn] |
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| | Yu, Chunqiu [VerfasserIn] |
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| | Zhou, Jun [VerfasserIn] |
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| | Han, Kang [VerfasserIn] |
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| | Sun, Hao [VerfasserIn] |
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| | Casini, Angela [VerfasserIn] |
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| | Ott, Ingo [VerfasserIn] |
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| | Wölfl, Stefan [VerfasserIn] |
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| Titel: | Elucidating the multimodal anticancer mechanism of an organometallic terpyridine platinum(II) N-heterocyclic carbene complex against triple-negative breast cancer In Vitro and In Vivo |
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| Verf.angabe: | Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A. Abu el Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, and Stefan Wölfl |
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| E-Jahr: | 2023 |
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| Jahr: | 10 March 2023 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 26.04.2023 |
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| Titel Quelle: | Enthalten in: Journal of medicinal chemistry |
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| Ort Quelle: | Washington, DC : ACS, 1959 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 66(2023), 6, Seite 3995-4008 |
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| ISSN Quelle: | 1520-4804 |
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| Abstract: | Treatment of triple-negative breast cancer (TNBC) has long been a medical challenge because of the lack of effective therapeutic targets. Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option in view of three heterogeneous metabolic-pathway-based TNBC subtypes. Here, we present a multimodal anticancer platinum(II) complex, named Pt(II)caffeine, with a novel mode of action involving simultaneous mitochondrial damage, inhibition of lipid, carbohydrate, and nucleotide metabolic pathways, and promotion of autophagy. All these biological processes eventually result in a strong suppression of TNBC MDA-MB-231 cell proliferation both in vitro and in vivo. The results indicate that Pt(II)caffeine, influencing cellular metabolism at multiple levels, is a metallodrug with increased potential to overcome the metabolic heterogeneity of TNBC. |
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| DOI: | doi:10.1021/acs.jmedchem.2c01925 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1021/acs.jmedchem.2c01925 |
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| | DOI: https://doi.org/10.1021/acs.jmedchem.2c01925 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1843586630 |
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| Verknüpfungen: | → Zeitschrift |
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Elucidating the multimodal anticancer mechanism of an organometallic terpyridine platinum(II) N-heterocyclic carbene complex against triple-negative breast cancer In Vitro and In Vivo / Zhang, Jing-Jing [VerfasserIn]; 10 March 2023 (Online-Ressource)
